MolNFT v1 · #87429 · protein
Dengue virus RNA dependent RNA polymerase with residues from the NS5 linker region
4C11 · Dengue virus type 3 RNA dependent RNA polymerase: “Dengue virus RNA dependent RNA polymerase with residues from the NS5 linker region”. X-ray diffraction, 1 ligand (ZN), 15 pockets (best druggability 0.75). MolNFT v1 #87429 on…
- PDB
- 4C11
- Type
- protein
- Length
- 1,196 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dengue virus type 3 RNA dependent RNA polymerase
- UniProt
- Q6DLV0
- Ligands
- ZN
- Pockets
- 15 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 49% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Dengue virus type 3 RNA dependent RNA polymerase | protein | 593 | 49% helix, 10% strand | Q6DLV0 |
| B | Dengue virus type 3 RNA dependent RNA polymerase | protein | 603 | 49% helix, 10% strand | Q6DLV0 |
Ligands and binding sites
- ZN · Zinc ion · metal · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
15 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 761 | 0.75 | 0.80 | 84 | empty |
| 2 | 503 | 0.66 | 0.78 | 69 | empty |
| 3 | 353 | 0.64 | 0.79 | 61 | empty |
| 4 | 452 | 0.62 | 0.76 | 34 | empty |
| 5 | 98 | 0.59 | 0.87 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 1659 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 4C11 · Dengue virus RNA dependent RNA polymerase with residues from the NS5 linker region · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6DLV0
- Elsewhere: RCSB PDB 4C11 · PDBe 4C11 · UniProt Q6DLV0
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