MolNFT v1 · #118507 · protein

Dengue serotype 3 RNA-dependent RNA polymerase bound to pc-79-SH52

5F3Z · Genome polyprotein: “Dengue serotype 3 RNA-dependent RNA polymerase bound to pc-79-SH52”. X-ray diffraction, 2 ligands (5V5, ZN), 5 pockets (best druggability 0.69). MolNFT v1 #118507 on GenesisL1: 3D structure, binding sites and…

PDB: 5F3Z
Type: protein
Length: 585 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Genome polyprotein
UniProt: Q6DLV0
Ligands: 5V5, ZN
Pockets: 5 · best druggability 0.69

Structure

x-ray diffraction · 1 distinct chain · 50% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Genome polyprotein	protein	585	50% helix, 10% strand	Q6DLV0

Ligands and binding sites

5V5 · 2-(4-methoxy-3-thiophen-2-yl-phenyl)ethanoic acid · ligand · chains A
ZN · Zinc ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	768	0.69	0.76	69	5V5
2	169	0.54	0.80	33	empty
3	93	0.45	0.80	25	empty
4	56	0.44	0.83	16	empty
5	53	0.25	0.73	15	empty

Compared structures

5F3Z · Dengue serotype 3 RNA-dependent RNA polymerase bound to PC-79-SH52 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6DLV0
Elsewhere: RCSB PDB 5F3Z · PDBe 5F3Z · UniProt Q6DLV0

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