UniProt Q63563
Isoform SUR2B of ATP-binding cassette sub-family C member 9 (Q63563)
Isoform SUR2B of ATP-binding cassette sub-family C member 9 (UniProt Q63563): 21 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 132 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q63563
- Protein
- Isoform SUR2B of ATP-binding cassette sub-family C member 9
- Experimental structures
- 21
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 132 · 9 records with a druggable one
Structures
22 records of Q63563 in the MolNFT archive: 21 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7MIT | Vascular KATP channel: Kir6.1 SUR2B propeller-like conformation 1 | electron microscopy | E | NAG, POV, PTY, ATP, GBM | — |
| 7MIT | Vascular katp channel: KIR6.1 SUR2B propeller-like conformation 1 | electron microscopy | E | NAG, POV, PTY, ATP, GBM | — |
| 7MJO | Vascular KATP channel: Kir6.1 SUR2B quatrefoil-like conformation 1 | electron microscopy | E, G | NAG, PTY, POV, ATP, GBM | 13 (best 0.86) |
| 7MJO | Vascular katp channel: KIR6.1 SUR2B quatrefoil-like conformation 1 | electron microscopy | E, G | NAG, PTY, POV, ATP, GBM | — |
| 7MJP | Vascular KATP channel: Kir6.1 SUR2B propeller-like conformation 2 | electron microscopy | E | NAG, ATP, GBM | 10 (best 0.80) |
| 7MJP | Vascular katp channel: KIR6.1 SUR2B propeller-like conformation 2 | electron microscopy | E | NAG, ATP, GBM | — |
| 7MJQ | Vascular KATP channel: Kir6.1 SUR2B quatrefoil-like conformation 2 | electron microscopy | E, G | NAG, ATP | 12 (best 0.77) |
| 7MJQ | Vascular katp channel: KIR6.1 SUR2B quatrefoil-like conformation 2 | electron microscopy | E, G | NAG, ATP | — |
| 7VLR | Structure of SUR2B in complex with Mg-ATP/ADP | electron microscopy | A | Y01, ADP, MG, ATP | — |
| 7VLR | Structure of SUR2B in complex with mg-ATP/ADP | electron microscopy | A | Y01, ADP, MG, ATP | — |
| 7VLS | Structure of SUR2B in complex with MgATP/ADP and P1075 | electron microscopy | A | Y01, ADP, MG, ATP, ESV | — |
| 7VLS | Structure of SUR2B in complex with MGATP/ADP and P1075 | electron microscopy | A | Y01, ADP, MG, ATP, ESV | — |
| 7VLT | Structure of SUR2B in complex with Mg-ATP/ADP and levcromakalim | electron microscopy | A | ETJ, Y01, ADP, MG, ATP | 19 (best 0.86) |
| 7VLT | Structure of SUR2B in complex with mg-ATP/ADP and levcromakalim | electron microscopy | A | ETJ, Y01, ADP, MG, ATP | — |
| 7VLU | Structure of SUR2A in complex with Mg-ATP/ADP and P1075 | electron microscopy | A | Y01, ADP, MG, ATP, ESV | 19 (best 0.87) |
| 7VLU | Structure of SUR2A in complex with mg-ATP/ADP and P1075 | electron microscopy | A | Y01, ADP, MG, ATP, ESV | — |
| 7Y1J | Structure of SUR2A in complex with Mg-ATP and repaglinide in the inward-facing conformation. | electron microscopy | A | ATP, MG, BJX | 13 (best 0.84) |
| 7Y1K | Structure of SUR2A in complex with Mg-ATP, Mg-ADP and repaglinide in the inward-facing conformation | electron microscopy | A | ATP, MG, BJX, ADP | 17 (best 0.85) |
| 7Y1L | Structure of SUR2B in complex with Mg-ATP and repaglinide in the inward-facing conformation | electron microscopy | A | MG, ATP, BJX | 15 (best 0.84) |
| 7Y1M | Structure of SUR2B in complex with Mg-ATP, Mg-ADP, and repaglinide in the inward-facing conformation | electron microscopy | A | MG, ATP, BJX, ADP | 14 (best 0.84) |
| 7Y1N | Structure of SUR2B in complex with Mg-ATP, Mg-ADP, and repaglinide in the partially occluded state | electron microscopy | A | ADP, MG, ATP, BJX | — |
| Q63563 | AlphaFold monomer V2.0 prediction for ATP-binding cassette sub-family C member 9 (Q63563) | predicted | A | — | — |
Ligands
- ATP · Adenosine-5'-triphosphate · in 21 records
- MG · Magnesium ion · in 13 records
- ADP · Adenosine-5'-diphosphate · in 11 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 8 records
- Y01 · Cholesterol hemisuccinate · in 8 records
- GBM · 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl) sulfamoyl]phenyl}ethyl)-2-methoxybenzamide · in 6 records
- BJX · Repaglinide · in 5 records
- ESV · 1-cyano-2-(2-methylbutan-2-yl)-3-pyridin-3-yl-guanidine · in 4 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 4 records
- PTY · Phosphatidylethanolamine · in 4 records
- ETJ · (3S,4R)-2,2-dimethyl-3-oxidanyl-4-(2-oxidanylidenepyrrolidin-1-yl)-3,4-dihydrochromene-6-carbonitrile · in 2 records
Experiment against prediction
- 7Y1K chain A against the predicted model Q63563: TM-score 0.98, RMSD 1.45 Å
- 7MJP chain E against the predicted model Q63563: TM-score 0.96, RMSD 2.72 Å
- 7MJP chain E against the predicted model Q63563: TM-score 0.96, RMSD 2.72 Å
- 7Y1M chain A against the predicted model Q63563: TM-score 0.96, RMSD 2.51 Å
- 7MIT chain E against the predicted model Q63563: TM-score 0.95, RMSD 2.74 Å
- 7MIT chain E against the predicted model Q63563: TM-score 0.95, RMSD 2.74 Å
- 7Y1L chain A against the predicted model Q63563: TM-score 0.95, RMSD 2.51 Å
- 7Y1J chain A against the predicted model Q63563: TM-score 0.95, RMSD 2.53 Å
- 7Y1N chain A against the predicted model Q63563: TM-score 0.95, RMSD 2.80 Å
- 7MJO chain G against the predicted model Q63563: TM-score 0.91, RMSD 1.90 Å
Elsewhere
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