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Ligand · ESV

ESV · 1-cyano-2-(2-methylbutan-2-yl)-3-pyridin-3-yl-guanidine

ESV, 1-cyano-2-(2-methylbutan-2-yl)-3-pyridin-3-yl-guanidine (C12 H17 N5, 231.3 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds…

Component
ESV
Formula
C12 H17 N5
Class
ligand
Structures
4
PDB entries
2

Binding sites

ESV in 4 structures; the first of them:

  • 7VLS · Structure of SUR2B in complex with MgATP/ADP and P1075 · ESV A1606 · binds ILE545, VAL548, PHE575, HIS576, VAL579, ILE1004, ILE1007, ASP1008 and 5 more
  • 7VLU · Structure of SUR2A in complex with Mg-ATP/ADP and P1075 · ESV A1606 · binds PRO544, ILE545, VAL548, HIS576, VAL579, HIS1001, ILE1004, ILE1007 and 6 more
  • 7VLS · Structure of SUR2B in complex with MGATP/ADP and P1075 · ESV A1606 · binds ILE545, VAL548, PHE575, HIS576, VAL579, ILE1004, ILE1007, ASP1008 and 5 more
  • 7VLU · Structure of SUR2A in complex with mg-ATP/ADP and P1075 · ESV A1606 · binds PRO544, ILE545, VAL548, HIS576, VAL579, ILE1004, ILE1007, ASP1008 and 5 more

Residues it binds most

ILE 4, TYR 4, VAL 4, HIS 4, ARG 4, ASP 4, LEU 4, THR 4, PHE 2, PRO 2 (residue and the binding sites it lines).

Found with

  • ADP · Adenosine-5'-diphosphate
  • ATP · Adenosine-5'-triphosphate
  • Y01 · Cholesterol hemisuccinate
  • MG · Magnesium ion

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