UniProt Q5VTY9
Protein-cysteine N-palmitoyltransferase HHAT (Q5VTY9)
Protein-cysteine N-palmitoyltransferase HHAT (UniProt Q5VTY9), EC 2.3.1.-: 14 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 20 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q5VTY9
- Protein
- Protein-cysteine N-palmitoyltransferase HHAT
- EC
- 2.3.1.-
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 20 · 2 records with a druggable one
Structures
15 records of Q5VTY9 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6UJO | Hhat L75F neoantigen peptide kqwlvwlfl presented by HLA-A206 | x-ray diffraction | C | — | — |
| 6UJQ | HHAT Wild Type Peptide KQWLVWLLL Presented by HLA-A206 | x-ray diffraction | C | — | — |
| 6UJQ | Hhat wild type peptide kqwlvwlll presented by HLA-A206 | x-ray diffraction | C | — | — |
| 6UK2 | Complex of T cell Receptor with HHAT Wild Type Peptide KQWLVWLLL Presented by HLA-A206 | x-ray diffraction | C | — | — |
| 6UK2 | Complex of T cell receptor with hhat wild type peptide kqwlvwlll presented by HLA-A206 | x-ray diffraction | C | — | — |
| 6UK4 | Complex of T cell receptor with hhat neoantigen peptide kqwlvwlfl presented by HLA-A206 | x-ray diffraction | C | — | — |
| 7MHY | Human hedgehog acyltransferase (hhat) in complex with palmitoyl-CoA and two Fab antibody fragments | electron microscopy | A | HEM, PKZ, AJP | — |
| 7MHZ | Human Hedgehog acyltransferase (HHAT) in complex with a palmitoylated Hedgehog peptide product and… | electron microscopy | A | PLM, HEM, PKZ, AJP | 9 (best 0.81) |
| 7MHZ | Human hedgehog acyltransferase (hhat) in complex with a palmitoylated hedgehog peptide product and… | electron microscopy | A | PLM, HEM, PKZ, AJP | — |
| 7Q1U | Structure of Hedgehog acyltransferase (HHAT) in complex with megabody 177 bound to non-hydrolysable… | electron microscopy | A | CLR, HEM, HD6, MG, PLM | — |
| 7Q1U | Structure of hedgehog acyltransferase (hhat) in complex with megabody 177 bound to non-hydrolysable… | electron microscopy | A | CLR, HEM, HD6, MG, PLM | — |
| 7Q6Z | Structure of Hedgehog acyltransferase (HHAT) in complex with megabody 177 bound to IMP-1575 | electron microscopy | A | CLR, HEM, 9V3, PLM | 11 (best 0.86) |
| 7Q6Z | Structure of hedgehog acyltransferase (hhat) in complex with megabody 177 bound to imp-1575 | electron microscopy | A | CLR, HEM, 9V3, PLM | — |
| 7URF | Human hhat H379C in complex with shh N-terminal peptide | electron microscopy | A | HEM, PKZ, AJP | — |
| Q5VTY9 | AlphaFold monomer V2.0 prediction for protein-cysteine N-palmitoyltransferase hhat (Q5VTY9) | predicted | A | — | — |
Ligands
- HEM · Protoporphyrin IX containing Fe · in 8 records
- PLM · Palmitic acid · in 6 records
- AJP · Digitonin · in 4 records
- CLR · Cholesterol · in 4 records
- PKZ · Palmitoyl-CoA · in 4 records
- 9V3 · 2-(2-methylpropylamino)-1-[(4R)-4-(6-methylpyridin-2-yl)-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]ethanone · in 2 records
- HD6 · [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(3~{S})-4-[[3-(2-hexadecylsulfanylethylamino)-3-oxidanylidene-propyl]amino]-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-butyl] hydrogen phosphate · in 2 records
- MG · Magnesium ion · in 2 records
Experiment against prediction
- 7Q1U chain A against the predicted model Q5VTY9: TM-score 0.99, RMSD 0.85 Å
- 7Q1U chain A against the predicted model Q5VTY9: TM-score 0.99, RMSD 0.85 Å
- 7Q6Z chain A against the predicted model Q5VTY9: TM-score 0.99, RMSD 0.88 Å
- 7Q6Z chain A against the predicted model Q5VTY9: TM-score 0.99, RMSD 0.88 Å
- 7MHZ chain A against the predicted model Q5VTY9: TM-score 0.99, RMSD 0.96 Å
- 7MHZ chain A against the predicted model Q5VTY9: TM-score 0.99, RMSD 0.96 Å
- 7MHY chain A against the predicted model Q5VTY9: TM-score 0.99, RMSD 1.03 Å
- 7URF chain A against the predicted model Q5VTY9: TM-score 0.99, RMSD 1.03 Å
- 6UJO chain C against the predicted model Q5VTY9: TM-score 0.40, RMSD 2.13 Å
- 6UJQ chain C against the predicted model Q5VTY9: TM-score 0.39, RMSD 0.36 Å
Elsewhere
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