MolNFT v1 · #182136 · protein
Human hedgehog acyltransferase (hhat) in complex with palmitoyl-CoA and two Fab antibody fragments
7MHY: “Human hedgehog acyltransferase (hhat) in complex with palmitoyl-CoA and two Fab antibody fragments”. Electron microscopy, 3 ligands (AJP, PKZ, HEM). MolNFT v1 #182136 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7MHY
- Type
- protein
- Length
- 912 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q5VTY9
- Ligands
- AJP, PKZ, HEM
Structure
electron microscopy · 5 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 491 | — | Q5VTY9 |
| M | — | protein | 118 | — | — |
| N | — | protein | 109 | — | — |
| O | — | protein | 100 | — | — |
| P | — | protein | 94 | — | — |
Ligands and binding sites
- AJP · Digitonin · ligand · 14 copies · chains A
- PKZ · Palmitoyl-CoA · ligand · 3 copies · chains A
- HEM · Protoporphyrin IX containing Fe · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7MHY · Human Hedgehog acyltransferase (HHAT) in complex with palmitoyl-CoA and two Fab antibody… · the same entry in another collection · chain A against A, TM-score 1.00
- Q5VTY9 · AlphaFold monomer V2.0 prediction for protein-cysteine N-palmitoyltransferase hhat… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5VTY9
- Elsewhere: RCSB PDB 7MHY · PDBe 7MHY · UniProt Q5VTY9
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