Structure of hedgehog acyltransferase (hhat) in complex with megabody 177 bound to non-hydrolysable palmitoyl-CoA (composite MAP)

Structure

electron microscopy · 2 distinct chains.

Ligands and binding sites

• PLM · Palmitic acid · ligand · 2 copies · chains A
• CLR · Cholesterol · ligand · chains A
• HEM · Protoporphyrin IX containing Fe · ligand · chains A
• HD6 · [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(3~{S})-4-[[3-(2-hexadecylsulfanylethylamino)-3-oxidanylidene-propyl]amino]-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-butyl] hydrogen phosphate · ligand · chains A
• MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7Q1U · Structure of Hedgehog acyltransferase (HHAT) in complex with megabody 177 bound to… · the same entry in another collection · chain A against A, TM-score 1.00
• Q5VTY9 · AlphaFold monomer V2.0 prediction for protein-cysteine N-palmitoyltransferase hhat… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q5VTY9
• Elsewhere: RCSB PDB 7Q1U · PDBe 7Q1U · UniProt Q5VTY9