UniProt Q5SJB8
Flavin-dependent thymidylate synthase (Q5SJB8)
Flavin-dependent thymidylate synthase (UniProt Q5SJB8), EC 2.1.1.148: 2 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 10 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q5SJB8
- Protein
- Flavin-dependent thymidylate synthase
- EC
- 2.1.1.148
- Experimental structures
- 2
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 10 · 1 record with a druggable one
Structures
3 records of Q5SJB8 in the MolNFT archive: 2 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6J61 | Crystal Structure of Thymidylate Synthase, Thy1, from Thermus thermophilus having an Extra C… | x-ray diffraction | A, B, C, D | FAD, PO4 | 7 (best 0.84) |
| 6J61 | Crystal structure of thymidylate synthase, THY1, from thermus thermophilus having an extra C… | x-ray diffraction | A, B, C, D | FAD, PO4 | — |
| Q5SJB8 | AlphaFold monomer V2.0 prediction for flavin-dependent thymidylate synthase (Q5SJB8) | predicted | A | — | 3 (best 0.46) |
Ligands
Experiment against prediction
- 6J61 chain B against the predicted model Q5SJB8: TM-score 0.97, RMSD 1.54 Å
- 6J61 chain B against the predicted model Q5SJB8: TM-score 0.97, RMSD 1.54 Å
- 6J61 chain A against the predicted model Q5SJB8: TM-score 0.97, RMSD 1.51 Å
- 6J61 chain A against the predicted model Q5SJB8: TM-score 0.97, RMSD 1.51 Å
- 6J61 chain C against the predicted model Q5SJB8: TM-score 0.97, RMSD 1.56 Å
- 6J61 chain C against the predicted model Q5SJB8: TM-score 0.97, RMSD 1.56 Å
- 6J61 chain D against the predicted model Q5SJB8: TM-score 0.95, RMSD 1.72 Å
Elsewhere
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