MolNFT v1 · #465363 · protein
AlphaFold monomer V2.0 prediction for flavin-dependent thymidylate synthase (Q5SJB8)
Q5SJB8: “AlphaFold monomer V2.0 prediction for flavin-dependent thymidylate synthase (Q5SJB8)”. 3 pockets (best druggability 0.46). MolNFT v1 #465363 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q5SJB8
- Type
- protein
- Length
- 270 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xC1B6297a2481813328d361F474DA565bfE4Ac044
- Molecule
- Flavin-dependent thymidylate synthase
- UniProt
- Q5SJB8
- Pockets
- 3 · best druggability 0.46
Structure
1 distinct chain · 50% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Flavin-dependent thymidylate synthase | protein | 270 | 50% helix, 17% strand | Q5SJB8 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 168 | 0.46 | 0.75 | 19 | empty |
| 2 | 92 | 0.35 | 0.74 | 12 | empty |
| 3 | 58 | 0.32 | 0.76 | 15 | empty |
Compared structures
- 6J61 · Crystal Structure of Thymidylate Synthase, Thy1, from Thermus thermophilus having an… · an experimental structure of the same protein · chain A against A, TM-score 0.87
- 6J61 · Crystal structure of thymidylate synthase, THY1, from thermus thermophilus having an… · an experimental structure of the same protein · chain A against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5SJB8
- Elsewhere: UniProt Q5SJB8 · AlphaFold DB Q5SJB8
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