UniProt Q5A4W8
Bromodomain-containing factor 1 (Q5A4W8)
Bromodomain-containing factor 1 (UniProt Q5A4W8): 10 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 8 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q5A4W8
- Protein
- Bromodomain-containing factor 1
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 8 · 1 record with a druggable one
Structures
11 records of Q5A4W8 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5N13 | Second Bromodomain (BD2) from Candida albicans Bdf1 in the unbound form | x-ray diffraction | A | — | 1 (best 0.47) |
| 5N13 | Second bromodomain (BD2) from candida albicans BDF1 in the unbound form | x-ray diffraction | A | — | — |
| 5N15 | First Bromodomain (BD1) from Candida albicans Bdf1 in the unbound form | x-ray diffraction | A, B, C, D | IOD | — |
| 5N15 | First bromodomain (BD1) from candida albicans BDF1 in the unbound form | x-ray diffraction | A, B, C, D | IOD | — |
| 5N16 | First Bromodomain (BD1) from Candida albicans Bdf1 bound to a dibenzothiazepi (compound 1) | x-ray diffraction | A, B, C, D | 8FN, NI | 5 (best 0.83) |
| 5N16 | First bromodomain (BD1) from candida albicans BDF1 bound to a dibenzothiazepinone (compound 1) | x-ray diffraction | A, B, C, D | 8FN, NI | — |
| 5N17 | First Bromodomain (BD1) from Candida albicans Bdf1 bound to a dibenzothiazepi (compound 3) | x-ray diffraction | A, B | 8FK, SO4 | — |
| 5N17 | First bromodomain (BD1) from candida albicans BDF1 bound to a dibenzothiazepinone (compound 3) | x-ray diffraction | A, B | 8FK, SO4 | — |
| 5N18 | Second Bromodomain (BD2) from Candida albicans Bdf1 bound to an imidazopyridine (compound 2) | x-ray diffraction | A, B | 8HZ | 2 (best 0.50) |
| 5N18 | Second bromodomain (BD2) from candida albicans BDF1 bound to an imidazopyridine (compound 2) | x-ray diffraction | A, B | 8HZ | — |
| Q5A4W8 | AlphaFold monomer V2.0 prediction for bromodomain-containing factor 1 (Q5A4W8) | predicted | A | — | — |
Ligands
- 8FK · (2~{S})-~{N}-(5-methyl-6-oxidanylidene-benzo[b][1, 4]benzothiazepin-2-yl)oxolane-2-carboxamide · in 2 records
- 8FN · 5-cyclopropyl-2-(5-pyrazin-2-yl-1,2,4-oxadiazol-3-yl) benzo[b][1,4]benzothiazepin-6-one · in 2 records
- 8HZ · 4-[8-methyl-3-[(4-methylphenyl)amino]imidazo[1,2-a]pyridin-2-yl]phenol · in 2 records
- IOD · Iodide ion · in 2 records
- NI · Nickel (II) ion · in 2 records
- SO4 · Sulfate ion · in 2 records
Experiment against prediction
- 5N16 chain B against the predicted model Q5A4W8: TM-score 0.99, RMSD 0.44 Å
- 5N16 chain B against the predicted model Q5A4W8: TM-score 0.99, RMSD 0.44 Å
- 5N16 chain D against the predicted model Q5A4W8: TM-score 0.99, RMSD 0.45 Å
- 5N16 chain D against the predicted model Q5A4W8: TM-score 0.99, RMSD 0.45 Å
- 5N15 chain D against the predicted model Q5A4W8: TM-score 0.99, RMSD 0.50 Å
- 5N15 chain D against the predicted model Q5A4W8: TM-score 0.99, RMSD 0.50 Å
- 5N15 chain B against the predicted model Q5A4W8: TM-score 0.98, RMSD 0.61 Å
- 5N15 chain B against the predicted model Q5A4W8: TM-score 0.98, RMSD 0.61 Å
- 5N16 chain A against the predicted model Q5A4W8: TM-score 0.98, RMSD 0.56 Å
- 5N16 chain A against the predicted model Q5A4W8: TM-score 0.98, RMSD 0.56 Å
Elsewhere
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