UniProt Q54527
Carminomycin 4-O-methyltransferase DnrK,Methyltransferase domain-containing protein,Aclacinomycin 10-hydroxylase RdmB (Q54527)
Carminomycin 4-O-methyltransferase DnrK,Methyltransferase domain-containing protein,Aclacinomycin 10-hydroxylase RdmB (UniProt Q54527), EC 2.1.1.292, 4.1.1.-: 17 experimental structures and 1 predicted model on GenesisL1, 8…
- UniProt
- Q54527
- Protein
- Carminomycin 4-O-methyltransferase DnrK,Methyltransferase domain-containing…
- EC
- 2.1.1.292, 4.1.1.-
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 53 · 10 records with a druggable one
Structures
18 records of Q54527 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1QZZ | Crystal structure of aclacinomycin-10-hydroxylase (RdmB) in complex with S-adenosyl-L-methionine… | x-ray diffraction | A | SAM | 2 (best 0.80) |
| 1QZZ | Crystal structure of aclacinomycin-10-hydroxylase (rdmb) in complex with S-adenosyl-L-methionine… | x-ray diffraction | A | — | — |
| 1R00 | Crystal structure of aclacinomycin-10-hydroxylase (RdmB) in complex with S-adenosyl-L-homocysteine… | x-ray diffraction | A | SAH | 2 (best 0.79) |
| 1R00 | Crystal structure of aclacinomycin-10-hydroxylase (rdmb) in complex with S-adenosyl-L-homocysteine… | x-ray diffraction | A | — | — |
| 1XDS | Crystal structure of Aclacinomycin-10-hydroxylase (RdmB) in complex with S-adenosyl-L-methionine… | x-ray diffraction | A, B | SAM, DRA | 6 (best 0.83) |
| 1XDS | Crystal structure of aclacinomycin-10-hydroxylase (rdmb) in complex with S-adenosyl-L-methionine… | x-ray diffraction | A, B | — | — |
| 1XDU | Crystal structure of Aclacinomycin-10-hydroxylase (RdmB) in complex with Sinefungin (SFG) | x-ray diffraction | A | SFG | 2 (best 0.79) |
| 1XDU | Crystal structure of aclacinomycin-10-hydroxylase (rdmb) in complex with sinefungin (sfg) | x-ray diffraction | A | — | — |
| 7OY1 | DnrK mutant RTCR | x-ray diffraction | A, B | SAH, 3VL | 6 (best 0.85) |
| 7OY1 | Dnrk mutant rtcr | x-ray diffraction | A, B | 3VL | — |
| 7PGA | Chimeric carminomycin-4-O-methyltransferase (DnrK) with regions from 10-hydroxylase RdmB and… | x-ray diffraction | A, B, C, D | SAH, VAK | 12 (best 0.84) |
| 7PGA | Chimeric carminomycin-4-O-methyltransferase (dnrk) with regions from 10-hydroxylase rdmb and… | x-ray diffraction | A, B, C, D | VAK | — |
| 7PGJ | Chimeric carminomycin-4-O-methyltransferase (DnrK) with regions from 10-decarboxylate TamK and… | x-ray diffraction | A | SAH, ZBX | 2 (best 0.77) |
| 7PGJ | Chimeric carminomycin-4-O-methyltransferase (dnrk) with regions from 10-decarboxylate tamk and… | x-ray diffraction | A | ZBX | — |
| 7PHE | Chimeric carminomycin-4-O-methyltransferase (DnrK) with regions from 10-hydroxylase RdmB and… | x-ray diffraction | A, B | VAK | — |
| 7PHF | Chimeric carminomycin-4-O-methyltransferase (DnrK) with regions from 10-hydroxylase RdmB and… | x-ray diffraction | A, B, C, D | SAH, VAK | 16 (best 0.85) |
| 9J56 | Functional Investigation of the SAM-Dependent Methyltransferases Rdmb in Anthracycline Biosynthesis | x-ray diffraction | A, B | SAH, A1L3V | 3 (best 0.87) |
| Q54527 | AlphaFold monomer V2.0 prediction for aclacinomycin 10-hydroxylase rdmb (Q54527) | predicted | A | — | 2 (best 0.77) |
Ligands
- SAH · S-adenosyl-L-homocysteine · in 6 records
- VAK · methyl (1R,2R,4S)-2-ethyl-2,4,5,7-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate · in 4 records
- 3VL · methyl (1R,2R,4S)-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-4-{[2,3,6-trideoxy-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl]oxy}-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate · in 2 records
- SAM · S-adenosylmethionine · in 2 records
- ZBX · methyl (1R,2R,4S)-2-ethyl-7-methoxy-2,4,5-tris(oxidanyl)-6,11-bis(oxidanylidene)-3,4-dihydro-1H-tetracene-1-carboxylate · in 2 records
- A1L3V · (7~{S},9~{S})-7-[(2~{R},4~{S},5~{S},6~{S})-4-azanyl-6-methyl-5-oxidanyl-oxan-2-yl]oxy-9-ethyl-4-methoxy-6,9,11-tris(oxidanyl)-8,10-dihydro-7~{H}-tetracene-5,12-dione · in 1 record
- DRA · 11-deoxy-beta-rhodomycin · in 1 record
- SFG · Sinefungin · in 1 record
Experiment against prediction
- 7PHF chain C against the predicted model Q06528: TM-score 0.97, RMSD 1.19 Å
- 7PGA chain B against the predicted model Q06528: TM-score 0.97, RMSD 1.27 Å
- 7PGJ chain A against the predicted model Q06528: TM-score 0.97, RMSD 1.18 Å
- 7PHF chain D against the predicted model Q06528: TM-score 0.97, RMSD 1.36 Å
- 7PGA chain B against the predicted model Q06528: TM-score 0.97, RMSD 1.27 Å
- 7PGA chain C against the predicted model Q06528: TM-score 0.97, RMSD 1.23 Å
- 7PGJ chain A against the predicted model Q06528: TM-score 0.97, RMSD 1.18 Å
- 7PGA chain C against the predicted model Q06528: TM-score 0.97, RMSD 1.23 Å
- 7PHF chain A against the predicted model Q06528: TM-score 0.96, RMSD 1.35 Å
- 7OY1 chain A against the predicted model Q06528: TM-score 0.96, RMSD 1.38 Å
Elsewhere
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