UniProt Q51504
Peptidoglycan D,D-transpeptidase FtsI (Q51504)
Peptidoglycan D,D-transpeptidase FtsI (UniProt Q51504), EC 2.4.1.129, 3.4.16.4: 40 experimental structures on GenesisL1, 11 ligands bound, 33 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q51504
- Protein
- Peptidoglycan D,D-transpeptidase FtsI
- EC
- 2.4.1.129, 3.4.16.4
- Experimental structures
- 40
- Predicted models
- 0
- Ligands
- 11
- Pockets
- 33 · 8 records with a druggable one
Structures
40 records of Q51504 in the MolNFT archive: 40 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3OC2 | Crystal structure of penicillin-binding protein 3 from Pseudomonas aeruginosa | x-ray diffraction | A | — | — |
| 3OC2 | Crystal structure of penicillin-binding protein 3 from pseudomonas aeruginosa | x-ray diffraction | A | — | — |
| 3OCL | Crystal structure of penicillin-binding protein 3 from Pseudomonas aeruginosa in complex with… | x-ray diffraction | A | — | — |
| 3OCL | Crystal structure of penicillin-binding protein 3 from pseudomonas aeruginosa in complex with… | x-ray diffraction | A | — | — |
| 3OCN | Crystal structure of penicillin-binding protein 3 from Pseudomonas aeruginosa in complex with… | x-ray diffraction | A | — | — |
| 3OCN | Crystal structure of penicillin-binding protein 3 from pseudomonas aeruginosa in complex with… | x-ray diffraction | A | — | — |
| 3PBN | Crystal Structure of Apo PBP3 from Pseudomonas aeruginosa | x-ray diffraction | A | — | — |
| 3PBN | Crystal structure of apo PBP3 from pseudomonas aeruginosa | x-ray diffraction | A | — | — |
| 3PBO | Crystal structure of PBP3 complexed with ceftazidime | x-ray diffraction | A | — | — |
| 3PBO | Crystal structure of PBP3 complexed with ceftazidime | x-ray diffraction | A | — | — |
| 3PBQ | Crystal structure of PBP3 complexed with imipenem | x-ray diffraction | A | — | — |
| 3PBQ | Crystal structure of PBP3 complexed with imipenem | x-ray diffraction | A | — | — |
| 3PBR | Crystal structure of PBP3 complexed with meropenem | x-ray diffraction | A | — | — |
| 3PBR | Crystal structure of PBP3 complexed with meropenem | x-ray diffraction | A | — | — |
| 3PBS | Crystal structure of PBP3 complexed with aztreonam | x-ray diffraction | A | — | — |
| 3PBS | Crystal structure of PBP3 complexed with aztreonam | x-ray diffraction | A | — | — |
| 3PBT | Crystal structure of PBP3 complexed with MC-1 | x-ray diffraction | A | — | — |
| 3PBT | Crystal structure of PBP3 complexed with mc-1 | x-ray diffraction | A | — | — |
| 4L0L | Crystal structure of P.aeruginosa PBP3 in complex with compound 4 | x-ray diffraction | A | — | — |
| 4L0L | Crystal structure of P.AERUGINOSA PBP3 in complex with compound 4 | x-ray diffraction | A | — | — |
| 5DF7 | Crystal structure of penicillin-binding protein 3 from pseudomonas aeruginosa in complex with… | x-ray diffraction | A, B | 59H, CL | 5 (best 0.81) |
| 5DF7 | Crystal structure of penicillin-binding protein 3 from pseudomonas aeruginosa in complex with… | x-ray diffraction | A, B | — | — |
| 5DF8 | Crystal structure of penicillin-binding protein 3 from pseudomonas aeruginosa in complex with… | x-ray diffraction | A, B | 59F, CL | 7 (best 0.79) |
| 5DF8 | Crystal structure of penicillin-binding protein 3 from pseudomonas aeruginosa in complex with… | x-ray diffraction | A, B | — | — |
| 5DF9 | Crystal structure of penicillin-binding protein 3 in complex with deacylated product of cefoperazone | x-ray diffraction | A | — | — |
| 6I1E | Crystal structure of Pseudomonas aeruginosa Penicillin-Binding Protein 3 in complex with amoxicillin | x-ray diffraction | A | AXL | — |
| 6I1E | Crystal structure of pseudomonas aeruginosa penicillin-binding protein 3 in complex with amoxicillin | x-ray diffraction | A | AXL | — |
| 6UN1 | Crystal structure of Pseudomonas aeruginosa PBP3 in complex with temocillin | x-ray diffraction | A | TJ7 | 4 (best 0.63) |
| 6UN1 | Crystal structure of pseudomonas aeruginosa PBP3 in complex with temocillin | x-ray diffraction | A | TJ7 | — |
| 6UN3 | Crystal structure of Pseudomonas aeruginosa PBP3 in complex with ticarcillin | x-ray diffraction | A | XT8, CA | 4 (best 0.60) |
| 6UN3 | Crystal structure of pseudomonas aeruginosa PBP3 in complex with ticarcillin | x-ray diffraction | A | XT8, CA | 4 (best 0.60) |
| 6VJE | Crystal structure of Pseudomonas aeruginosa penicillin-binding protein 3 (PBP3) complexed with… | x-ray diffraction | A | CL | — |
| 6VJE | Crystal structure of pseudomonas aeruginosa penicillin-binding protein 3 (PBP3) complexed with… | x-ray diffraction | A | CL | — |
| 6VOT | Crystal structure of pseudomonas aerugonisa PBP3 complexed to gamma- lactam YU253434 | x-ray diffraction | A | R7G | — |
| 7JWL | Crystal Structure of Pseudomonas aeruginosa Penicillin Binding Protein 3 (PAE-PBP3) bound to ETX0462 | x-ray diffraction | A | CL, VMM | 4 (best 0.57) |
| 7JWL | Crystal structure of pseudomonas aeruginosa penicillin binding protein 3 (pae-PBP3) bound to ETX0462 | x-ray diffraction | A | CL, VMM | — |
| 7LC4 | Crystal structure of Pseudomonas aeruginosa PBP3 in complex with gamma-lactam YU253911 | x-ray diffraction | A | XVG | 2 (best 0.63) |
| 7LC4 | Crystal structure of pseudomonas aeruginosa PBP3 in complex with gamma-lactam YU253911 | x-ray diffraction | A | XVG | — |
| 7LY1 | Crystal structure of Pseudomonas aeruginosa PBP3 in complex with vaborbactam | x-ray diffraction | A | 4D6 | 3 (best 0.56) |
| 7LY1 | Crystal structure of pseudomonas aeruginosa PBP3 in complex with vaborbactam | x-ray diffraction | A | 4D6 | — |
Ligands
- CL · Chloride ion · in 6 records
- 4D6 · Vaborbactam · in 2 records
- AXL · 2-{1-[2-amino-2-(4-hydroxy-phenyl)-acetylamino]-2-oxo-ethyl}-5,5-dimethyl-thiazolidine-4-carboxylic acid · in 2 records
- CA · Calcium ion · in 2 records
- TJ7 · (2R,4S)-2-[(1S)-1-{[(2R)-2-carboxy-2-(thiophen-3-yl) acetyl]amino}-1-methoxy-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid · in 2 records
- VMM · ETX0462 (Bound form) · in 2 records
- XT8 · (2R,4S)-2-[(1R)-1-{[(2R)-2-carboxy-2-(thiophen-3-yl) acetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid · in 2 records
- XVG · 1-[(2S)-2-{[(2Z)-2-(2-amino-5-chloro-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-3-oxopropyl]-4-{[2-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]carbamoyl}-2,5-dihydro-1H-pyrazole-3-carboxylic acid · in 2 records
- 59F · (2R,4R,5R)-2-[(1R)-1-{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-(4-hydroxyphenyl)acetyl]amino}-2-oxoethyl]-5-methyl-1,3-thiazinane-4-carboxylic acid · in 1 record
- 59H · (2R,4S)-5,5-dimethyl-2-[(1R)-2-oxo-1-{[(2R)-2-{[(2-oxoimidazolidin-1-yl)carbonyl]amino}-2-phenylacetyl]amino}ethyl]-1,3-thiazolidine-4-carboxylic acid · in 1 record
- R7G · 1-[(2S)-2-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-3-oxopropyl]-4-{[2-(5,6 -dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]carbamoyl}-2,5-dihydro-1H-pyrazole-3-carboxylic acid · in 1 record
Elsewhere
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