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Ligand · CAZ

CAZ · Acylated ceftazidime

CAZ, Acylated ceftazidime (C17 H19 N5 O7 S2, 469.5 g/mol), in the MolNFT structures on GenesisL1: bound in 16 records (12 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found…

Component
CAZ
Formula
C17 H19 N5 O7 S2
Class
ligand
Structures
16
PDB entries
12

Binding sites

CAZ in 16 structures; the first of them:

  • 5TW6 · CTX-M-14 P167S:E166A mutant with acylated ceftazidime molecule · CAZ A301 · binds CYS69, SER70, LYS73, ASN104, TYR105, SER130, ASN132, ASN170 and 10 more
  • 5TWE · CTX-M-14 P167S:S70G mutant enzyme crystallized with ceftazidime · CAZ A301 · binds CYS69, GLY70, ASN104, TYR105, SER130, ASN132, SER167, ASN170 and 7 more
  • 5U53 · CTX-M-14 E166A with acylated ceftazidime molecule · CAZ A301 · binds CYS69, SER70, LYS73, ASN104, TYR105, SER130, ASN132, PRO167 and 9 more
  • 6LC9 · Crystal structure of AmpC Ent385 complex form with ceftazidime · CAZ A401 · binds SER64, LYS67, LEU119, GLN120, TYR150, ASN152, VAL211, TYR221 and 8 more
  • 9FZ7 · Pseudomonas aeruginosa penicillin binding protein 3 in complex with cefiderocol · CAZ A601 · binds GLU242, GLY244, SER245A, LYS248, VAL284, SER300, ASN302, TYR358 and 12 more
  • 9FZO · Pseudomonas aeruginosa penicillin binding protein 3 in complex with ceftazidime · CAZ A601 · binds GLU242, GLY244, SER245, LYS248, VAL284, SER300, ASN302, TYR358 and 12 more
  • 5TW6 · Ctx-M-14 P167S:E166A mutant with acylated ceftazidime molecule · CAZ A301 · binds CYS69, SER70, ASN104, TYR105, SER130, ASN132, ASN170, THR171 and 9 more
  • 5TWE · Ctx-M-14 P167S:S70G mutant enzyme crystallized with ceftazidime · CAZ A301 · binds CYS69, GLY70, ASN104, TYR105, SER130, ASN132, SER167, ASN170 and 7 more
  • 5U53 · Ctx-M-14 E166A with acylated ceftazidime molecule · CAZ A301 · binds CYS69, SER70, LYS73, ASN104, TYR105, SER130, ASN132, PRO167 and 7 more
  • 6LC9 · Crystal structure of ampc ENT385 complex form with ceftazidime · CAZ A401 · binds SER64, LYS67, LEU119, GLN120, TYR150, ASN152, VAL211, TYR221 and 8 more
  • 6PWM · Adc-7 in complex with beta-lactam antibiotic ceftazidime · CAZ A401 · binds SER64, LEU119, GLN120, TYR150, ASN152, VAL212, TYR222, VAL292 and 7 more
  • 6V7T · Crystal structure of ctx-M-14 E166A/D240G beta-lactamase in complex with ceftazidime · CAZ A301 · binds CYS69, SER70, ASN104, TYR105, SER130, ASN132, PRO167, ASN170 and 7 more
  • 6V83 · Crystal structure of ctx-M-14 E166A/P167S/D240G beta-lactamase in complex with… · CAZ A301 · binds CYS69, SER70, LYS73, ASN104, TYR105, SER130, ASN132, SER167 and 7 more
  • 6V8V · Crystal structure of ctx-M-14 E166A/P167S/D240G beta-lactamase in complex with… · CAZ A301 · binds CYS69, SER70, ASN104, TYR105, SER130, ASN132, ASN170, THR171 and 7 more
  • 6Z24 · Acylenzyme complex of ceftazidime bound to deacylation mutant kpc-2 (E166Q) · CAZ A301 · binds CYS69, SER70, TRP105, SER130, ASN132, ARG220, LYS234, THR235 and 5 more
  • 6Z25 · Acylenzyme complex of ceftazidime bound to deacylation mutant kpc-4 (E166Q) · CAZ A305 · binds CYS69, SER70, ARG104, TRP105, SER130, ASN132, ASN170, SER171 and 7 more

Residues it binds most

SER 22, GLY 22, ASN 22, THR 22, TYR 20, LYS 18, CYS 12, VAL 9, ARG 10, LEU 8 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion
  • GOL · Glycerol
  • NO3 · Nitrate ion
  • DIO · 1,4-diethylene dioxide
  • EDO · 1,2-ethanediol

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