UniProt Q4QEW7
Dihydroorotate dehydrogenase (Q4QEW7)
Dihydroorotate dehydrogenase (UniProt Q4QEW7), EC 1.3.3.1, 1.3.98.1: 26 experimental structures on GenesisL1, 11 ligands bound, 136 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q4QEW7
- Protein
- Dihydroorotate dehydrogenase
- EC
- 1.3.3.1, 1.3.98.1
- Experimental structures
- 26
- Predicted models
- 0
- Ligands
- 11
- Pockets
- 136 · 26 records with a druggable one
Structures
26 records of Q4QEW7 in the MolNFT archive: 26 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3GYE | Didydroorotate dehydrogenase from Leishmania major | x-ray diffraction | A, B | FMN | 4 (best 0.80) |
| 3GYE | Didydroorotate dehydrogenase from leishmania major | x-ray diffraction | A, B | FMN | 4 (best 0.80) |
| 3GZ3 | Leishmania major Dihydroorotate Dehydrogenase in complex with orotate | x-ray diffraction | A, B | FMN, ORO | 3 (best 0.79) |
| 3GZ3 | Leishmania major dihydroorotate dehydrogenase in complex with orotate | x-ray diffraction | A, B | FMN, ORO | 3 (best 0.79) |
| 3MHU | Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with… | x-ray diffraction | A, B | FMN, EJZ, SO4 | 5 (best 0.78) |
| 3MHU | Crystal structure of dihydroorotate dehydrogenase from leishmania major in complex with… | x-ray diffraction | A, B | FMN, EJZ, SO4 | 5 (best 0.78) |
| 3MJY | Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with… | x-ray diffraction | A, B | FMN, IJZ, SO4 | 5 (best 0.74) |
| 3MJY | Crystal structure of dihydroorotate dehydrogenase from leishmania major in complex with… | x-ray diffraction | A, B | FMN, IJZ, SO4 | 5 (best 0.74) |
| 3TJX | Crystal Structure of Leishmania major dihydroorotate dehydrogenase mutant H174A | x-ray diffraction | A, B | FMN, SO4 | 5 (best 0.75) |
| 3TJX | Crystal structure of leishmania major dihydroorotate dehydrogenase mutant H174A | x-ray diffraction | A, B | FMN, SO4 | 5 (best 0.75) |
| 3TQ0 | Crystal structure of Leishmania major dihydroorotate dehydrogenase in complex with fumarate | x-ray diffraction | A, B | FMN, FUM, NI, SO4 | 7 (best 0.78) |
| 3TQ0 | Crystal structure of leishmania major dihydroorotate dehydrogenase in complex with fumarate | x-ray diffraction | A, B | FMN, FUM, NI, SO4 | 7 (best 0.78) |
| 3TRO | Crystal Structure of Leishmania major dihydroorotate dehydrogenase mutant D171A | x-ray diffraction | A, B | FMN, SO4 | 6 (best 0.76) |
| 3TRO | Crystal structure of leishmania major dihydroorotate dehydrogenase mutant D171A | x-ray diffraction | A, B | FMN, SO4 | 6 (best 0.76) |
| 4EF8 | Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with Phenyl… | x-ray diffraction | A, B | FMN, 0FI, SO4 | 5 (best 0.79) |
| 4EF8 | Crystal structure of dihydroorotate dehydrogenase from leishmania major in complex with phenyl… | x-ray diffraction | A, B | FMN, 0FI, SO4 | 5 (best 0.79) |
| 4EF9 | Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with… | x-ray diffraction | A, B | 4NF, FMN, SO4 | 7 (best 0.79) |
| 4EF9 | Crystal structure of dihydroorotate dehydrogenase from leishmania major in complex with… | x-ray diffraction | A, B | 4NF, FMN, SO4 | 7 (best 0.79) |
| 6DGS | Crystal Structure of Leishmania major dihydroorotate dehydrogenase mutant Y142A | x-ray diffraction | A, B | FMN, SO4 | 3 (best 0.80) |
| 6DGS | Crystal structure of leishmania major dihydroorotate dehydrogenase mutant Y142A | x-ray diffraction | A, B | FMN, SO4 | 3 (best 0.80) |
| 6DWG | Crystal structure of Leishmania major dihydroorotate dehydrogenase mutant Q139A | x-ray diffraction | A, B | FMN, SO4, NI | 5 (best 0.76) |
| 6DWG | Crystal structure of leishmania major dihydroorotate dehydrogenase mutant Q139A | x-ray diffraction | A, B | FMN, SO4, NI | 5 (best 0.76) |
| 6EBS | Crystal structure of Leishmania major dihydroorotate dehydrogenase mutant H174A in complex with… | x-ray diffraction | A, B | FMN, ORO, SO4, NI | 8 (best 0.79) |
| 6EBS | Crystal structure of leishmania major dihydroorotate dehydrogenase mutant H174A in complex with… | x-ray diffraction | A, B | FMN, ORO, SO4, NI | 8 (best 0.79) |
| 7MX6 | Leishmania major dihydroorotate dehydrogenase in complex with [4-(1H-pyrrol-1-yl)phenyl]methanol | x-ray diffraction | AAA, BBB | FMN, SNU, SO4 | 5 (best 0.75) |
| 7MYD | Leishmania major dihydroorotate dehydrogenase in complex with 5-amino-2-(1H-pyrrol-1-yl)benzonitrile | x-ray diffraction | AAA, BBB | FMN, SO4, SNQ | 5 (best 0.76) |
Ligands
- FMN · Flavin mononucleotide · in 26 records
- SO4 · Sulfate ion · in 22 records
- NI · Nickel (II) ion · in 6 records
- ORO · Orotic acid · in 4 records
- 0FI · N-phenylthioformamide · in 2 records
- 4NF · N-(4-nitrophenyl)thioformamide · in 2 records
- EJZ · 5-nitro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid · in 2 records
- FUM · Fumaric acid · in 2 records
- IJZ · 5-amino-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid · in 2 records
- SNQ · 5-azanyl-2-pyrrol-1-yl-benzenecarbonitrile · in 1 record
- SNU · 4-(1H-pyrrol-1-yl)aniline · in 1 record
Elsewhere
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