UniProt Q38C91
Methionyl-tRNA synthetase (Q38C91)
Methionyl-tRNA synthetase (UniProt Q38C91), EC 6.1.1.10: 73 experimental structures on GenesisL1, 38 ligands bound, 969 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q38C91
- Protein
- Methionyl-tRNA synthetase
- EC
- 6.1.1.10
- Experimental structures
- 73
- Predicted models
- 0
- Ligands
- 38
- Pockets
- 969 · 70 records with a druggable one
Structures
73 records of Q38C91 in the MolNFT archive: 73 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4EG1 | Trypanosoma brucei methionyl-tRNA synthetase in complex with substrate Methionine | x-ray diffraction | A, B | MET | 12 (best 0.77) |
| 4EG1 | Trypanosoma brucei methionyl-tRNA synthetase in complex with substrate methionine | x-ray diffraction | A, B | MET | 12 (best 0.77) |
| 4EG3 | Trypanosoma brucei methionyl-tRNA synthetase in complex with product methionyl-adenylate | x-ray diffraction | A, B | ME8 | 15 (best 0.77) |
| 4EG3 | Trypanosoma brucei methionyl-tRNA synthetase in complex with product methionyl-adenylate | x-ray diffraction | A, B | ME8 | 15 (best 0.77) |
| 4EG4 | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor Chem 1289 | x-ray diffraction | A, B | MET, SO4, 0OT | 14 (best 0.80) |
| 4EG4 | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor chem 1289 | x-ray diffraction | A, B | MET, SO4, 0OT | 14 (best 0.80) |
| 4EG5 | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor Chem 1312 | x-ray diffraction | A, B | MET, SO4, 0OU | 15 (best 0.75) |
| 4EG5 | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor chem 1312 | x-ray diffraction | A, B | MET, SO4, 0OU | 15 (best 0.75) |
| 4EG6 | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor Chem 1325 | x-ray diffraction | A, B | MET, SO4, 0P5 | 17 (best 0.74) |
| 4EG6 | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor chem 1325 | x-ray diffraction | A, B | MET, SO4, 0P5 | 17 (best 0.74) |
| 4EG7 | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor Chem 1331 | x-ray diffraction | A, B | MET, 0P4 | 13 (best 0.77) |
| 4EG7 | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor chem 1331 | x-ray diffraction | A, B | MET, 0P4 | 13 (best 0.77) |
| 4EG8 | Trypanosoma brucei methionyl-tRNA synthetase in complex with compound Chem 89 | x-ray diffraction | A, B | MET, 0P6 | 14 (best 0.77) |
| 4EG8 | Trypanosoma brucei methionyl-tRNA synthetase in complex with compound chem 89 | x-ray diffraction | A, B | MET, 0P6 | 14 (best 0.77) |
| 4EGA | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor Chem 1320 | x-ray diffraction | A, B | MET, SO4, 0P8 | 16 (best 0.76) |
| 4EGA | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor chem 1320 | x-ray diffraction | A, B | MET, SO4, 0P8 | 16 (best 0.76) |
| 4MVW | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | MET, SO4, 43E | 17 (best 0.75) |
| 4MVW | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | MET, SO4, 43E | 17 (best 0.75) |
| 4MVX | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | MET, C13 | 16 (best 0.76) |
| 4MVX | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | MET, C13 | 16 (best 0.76) |
| 4MVY | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | MET, 387 | 12 (best 0.77) |
| 4MVY | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | MET, 387 | 12 (best 0.77) |
| 4MW0 | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | MET, 392 | 13 (best 0.76) |
| 4MW0 | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | MET, 392 | 13 (best 0.76) |
| 4MW1 | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | MET, 44F | 12 (best 0.77) |
| 4MW1 | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | MET, 44F | 12 (best 0.77) |
| 4MW2 | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | SO4, MET, 2E9 | 11 (best 0.76) |
| 4MW2 | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | SO4, MET, 2E9 | 11 (best 0.76) |
| 4MW4 | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | SO4, MET, 2EB | 15 (best 0.76) |
| 4MW4 | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | SO4, MET, 2EB | 15 (best 0.76) |
| 4MW5 | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | MET, SO4, 415 | 13 (best 0.75) |
| 4MW5 | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | MET, SO4, 415 | 13 (best 0.75) |
| 4MW6 | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | MET, 2EE | 12 (best 0.76) |
| 4MW6 | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | MET, 2EE | 12 (best 0.76) |
| 4MW7 | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | MET, SO4, 2EF | 15 (best 0.77) |
| 4MW7 | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | MET, SO4, 2EF | 15 (best 0.77) |
| 4MW9 | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | SO4, MET, 2EJ | 12 (best 0.77) |
| 4MW9 | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | SO4, MET, 2EJ | 12 (best 0.77) |
| 4MWB | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | MET, SO4, 2EK | 12 (best 0.77) |
| 4MWB | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | MET, SO4, 2EK | 12 (best 0.77) |
| 4MWC | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | SO4, MET, 2EM | 13 (best 0.76) |
| 4MWC | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | SO4, MET, 2EM | 13 (best 0.76) |
| 4MWD | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | SO4, MET, 43E, ACP | 11 (best 0.77) |
| 4MWD | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | SO4, MET, 43E, ACP | 11 (best 0.77) |
| 4MWE | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | SO4, MET, 2EN | 11 (best 0.75) |
| 4MWE | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | SO4, MET, 2EN | 11 (best 0.75) |
| 4ZT2 | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | MET, 4RP, SO4 | 14 (best 0.76) |
| 4ZT2 | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | MET, 4RP, SO4 | 14 (best 0.76) |
| 4ZT3 | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | MET, SO4, 4RQ | 14 (best 0.76) |
| 4ZT3 | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | MET, SO4, 4RQ | 14 (best 0.76) |
| 4ZT4 | Trypanosoma brucei methionyl-tRNA synthetase in complex with… | x-ray diffraction | A, B | MET, SO4, 4RO | 14 (best 0.75) |
| 4ZT4 | Trypanosoma brucei methionyl-tRNA synthetase in complex with… | x-ray diffraction | A, B | MET, SO4, 4RO | 14 (best 0.75) |
| 4ZT5 | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | MET, SO4, 4RN | 13 (best 0.75) |
| 4ZT5 | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | MET, SO4, 4RN | 13 (best 0.75) |
| 4ZT6 | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | MET, 4RD | 14 (best 0.76) |
| 4ZT6 | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | MET, 4RD | 14 (best 0.76) |
| 4ZT7 | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… | x-ray diffraction | A, B | MET, 4RC | 16 (best 0.76) |
| 5J58 | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor (Chem 1856) | x-ray diffraction | A, B | MET, N56 | 15 (best 0.76) |
| 5J58 | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor (chem 1856) | x-ray diffraction | A, B | MET, N56 | 15 (best 0.76) |
| 5J59 | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor (Chem 1893) | x-ray diffraction | A, B | MET, N93 | 13 (best 0.76) |
13 records more on the page itself.
Ligands
- MET · Methionine · in 68 records
- SO4 · Sulfate ion · in 38 records
- 43E · 1-{3-[(3,5-dichlorobenzyl)amino]propyl}-3-thiophen-3-ylurea · in 4 records
- 0OT · 2-({3-[(3,5-dibromo-2-ethoxybenzyl)amino]propyl}amino)quinolin-4(1H)-one · in 2 records
- 0OU · 2-({3-[(3,5-dichlorobenzyl)amino]propyl}amino)quinolin-4(1H)-one · in 2 records
- 0P4 · N-(1H-benzimidazol-2-yl)-N'-(3,5-dichlorobenzyl)propane-1,3-diamine · in 2 records
- 0P5 · 4-{4-[(1H-benzimidazol-2-ylmethyl)amino]-6-(2-chloro-4-methoxyphenoxy)pyrimidin-2-yl}piperazin-2-one · in 2 records
- 0P6 · 2-aminoquinolin-8-ol · in 2 records
- 0P8 · 2-({3-[(3,5-dibromo-2-methoxybenzyl)amino]propyl}amino)quinolin-4(1H)-one · in 2 records
- 2E9 · 1-(3-{[5-chloro-2-hydroxy-3-(prop-2-en-1-yl)benzyl]amino}propyl)-3-thiophen-3-ylurea · in 2 records
- 2EB · 1-{3-[(5-chloro-2-hydroxy-3-iodobenzyl)amino]propyl}-3-thiophen-3-ylurea · in 2 records
- 2EE · 1-(3-{[2-(benzyloxy)-5-chloro-3-(prop-2-en-1-yl)benzyl]amino}propyl)-3-thiophen-3-ylurea · in 2 records
- 2EF · 1-{3-[(5-chloro-2-ethoxy-3-iodobenzyl)amino]propyl}-3-thiophen-3-ylurea · in 2 records
- 2EJ · 1-{3-[(3-ethynylbenzyl)amino]propyl}-3-thiophen-3-ylurea · in 2 records
- 2EK · 1-(3-{[(2,5-dichlorothiophen-3-yl)methyl]amino}propyl)-3-thiophen-3-ylurea · in 2 records
- 2EM · 1-(3-{[(2-methyl-1-benzothiophen-3-yl)methyl]amino}propyl)-3-thiophen-3-ylurea · in 2 records
- 2EN · 1-(3-{[5-chloro-3-(prop-2-en-1-yl)-2-(prop-2-en-1-yloxy)benzyl]amino}propyl)-3-thiophen-3-ylurea · in 2 records
- 387 · 1-{3-[(3,5-dichlorobenzyl)amino]propyl}-3-(3-hydroxyphenyl)urea · in 2 records
- 392 · 1-{3-[(3,5-dichlorobenzyl)amino]propyl}-3-(2-hydroxyphenyl)urea · in 2 records
- 415 · 1-{3-[(3-chloro-5-methoxybenzyl)amino]propyl}-3-phenylurea · in 2 records
- 44F · 1-{3-[(3-chloro-5-methoxybenzyl)amino]propyl}-3-thiophen-3-ylurea · in 2 records
- 4RD · N-[(4R)-6,8-dichloro-3,4-dihydro-2H-chromen-4-yl]-N'-(5-fluoro-1H-imidazo[4,5-b]pyridin-2-yl)propane-1,3-diamine · in 2 records
- 4RN · (2S)-N-(3,5-dichlorobenzyl)-N'-(1H-imidazo[4,5-b]pyridin-2-yl)-2-methylpropane-1,3-diamine · in 2 records
- 4RO · N-(3,5-dichlorobenzyl)-2,2-difluoro-N'-(1H-imidazo[4,5-b]pyridin-2-yl)propane-1,3-diamine · in 2 records
- 4RP · N-(3,5-dichlorobenzyl)-N'-(1H-imidazo[4,5-b]pyridin-2-yl)propane-1,3-diamine · in 2 records
- 4RQ · N-(3,5-dichlorobenzyl)-N'-(5-fluoro-1H-imidazo[4,5-b]pyridin-2-yl)propane-1,3-diamine · in 2 records
- 756 · [(3S)-3-(1H-benzimidazol-2-yl)piperidin-1-yl](2-methyl-1-benzofuran-5-yl)methanone · in 2 records
- 8W2 · 2-[3-[[4,6-bis(chloranyl)-1~{H}-indol-2-yl]methylamino]propylamino]-3~{H}-quinazolin-4-one · in 2 records
- 8WA · N~1~-(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)-N~2~-[(4R)-6,8-dichloro-1,2,3,4-tetrahydroquinolin-4-yl]-N~1~-methylethane-1,2-diamine · in 2 records
- 96S · 1-[(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)methyl]-4-[(2-chloro-4-methoxyphenyl)methyl]-3-ethyl-1,3-dihydro-2H-imidazol-2-one · in 2 records
Elsewhere
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