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Ligand · 4RD

4RD · N-[(4R)-6,8-dichloro-3,4-dihydro-2H-chromen-4-yl]-N'-(5-fluoro-1H-imidazo[4,5-b]pyridin-2-yl)propane-1,3-diamine

4RD, N-[(4R)-6,8-dichloro-3,4-dihydro-2H-chromen-4-yl]-N'-(5-fluoro-1H-imidazo[4,5-b]pyridin-2-yl)propane-1,3-diamine (C18 H18 Cl2 F N5 O, 410.3 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding…

Component
4RD
Formula
C18 H18 Cl2 F N5 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

4RD in 2 structures; the first of them:

  • 4ZT6 · Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… · 4RD B802 · binds PRO247, ILE248, TYR250, ASP287, HIS289, GLY290, LEU456, ALA460 and 11 more
  • 4ZT6 · Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor… · 4RD B802 · binds PRO247, ILE248, TYR250, ASP287, HIS289, GLY290, LEU456, ALA460 and 11 more

Residues it binds most

TYR 2, ALA 2, ASP 2, HIS 2, ILE 2, LEU 2, VAL 2, GLY 2, PHE 2, PRO 2 (residue and the binding sites it lines).

Found with

  • MET · Methionine
  • DMS · Dimethyl sulfoxide

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