UniProt Q2RMD6
Pyruvate-ferredoxin oxidoreductase (Q2RMD6)
Pyruvate-ferredoxin oxidoreductase (UniProt Q2RMD6), EC 1.2.7.-: 8 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 92 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q2RMD6
- Protein
- Pyruvate-ferredoxin oxidoreductase
- EC
- 1.2.7.-
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 92 · 5 records with a druggable one
Structures
9 records of Q2RMD6 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6CIN | Crystal structure of pyruvate:ferredoxin oxidoreductase from Moorella thermoacetica | x-ray diffraction | A, B, C, D, E, F | SF4, TPP, MG, SO4 | 20 (best 0.87) |
| 6CIN | Crystal structure of PYRUVATE:FERREDOXIN oxidoreductase from moorella thermoacetica | x-ray diffraction | A, B, C, D, E, F | SF4, TPP, MG, SO4 | — |
| 6CIO | Pyruvate:ferredoxin oxidoreductase from Moorella thermoacetica with lactyl-TPP bound | x-ray diffraction | A, B, C, D, E, F | SF4, TDL, MG, SO4, TPP | 20 (best 0.87) |
| 6CIO | PYRUVATE:FERREDOXIN oxidoreductase from moorella thermoacetica with lactyl-tpp bound | x-ray diffraction | A, B, C, D, E, F | SF4, TDL, MG, SO4, TPP | — |
| 6CIP | Pyruvate:ferredoxin oxidoreductase from Moorella thermoacetica with acetyl-TPP bound | x-ray diffraction | A, B, C, D, E, F | SF4, HTL, MG, SO4 | 20 (best 0.86) |
| 6CIP | PYRUVATE:FERREDOXIN oxidoreductase from moorella thermoacetica with acetyl-tpp bound | x-ray diffraction | A, B, C, D, E, F | SF4, HTL, MG, SO4 | — |
| 6CIQ | Pyruvate:ferredoxin oxidoreductase from Moorella thermoacetica with coenzyme A bound | x-ray diffraction | A, B, C | SF4, TPP, MG, COA | 20 (best 0.86) |
| 6CIQ | PYRUVATE:FERREDOXIN oxidoreductase from moorella thermoacetica with coenzyme a bound | x-ray diffraction | A, B, C | SF4, TPP, MG, COA | — |
| Q2RMD6 | AlphaFold monomer V2.0 prediction for PYRUVATE:FERREDOXIN oxidoreductase (Q2RMD6) | predicted | A | — | 12 (best 0.82) |
Ligands
- MG · Magnesium ion · in 8 records
- SF4 · Iron/sulfur cluster · in 8 records
- SO4 · Sulfate ion · in 6 records
- TPP · Thiamine diphosphate · in 6 records
- COA · Coenzyme A · in 2 records
- HTL · 2-acetyl-thiamine diphosphate · in 2 records
- TDL · 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-carboxy-1-hydroxyethyl)-5-(2-{[hydroxy(phosphonooxy) phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium · in 2 records
Experiment against prediction
- 6CIO chain C against the predicted model Q2RMD6: TM-score 1.00, RMSD 0.77 Å
- 6CIO chain C against the predicted model Q2RMD6: TM-score 1.00, RMSD 0.77 Å
- 6CIN chain C against the predicted model Q2RMD6: TM-score 1.00, RMSD 0.78 Å
- 6CIN chain C against the predicted model Q2RMD6: TM-score 1.00, RMSD 0.78 Å
- 6CIO chain E against the predicted model Q2RMD6: TM-score 0.99, RMSD 0.79 Å
- 6CIO chain E against the predicted model Q2RMD6: TM-score 0.99, RMSD 0.79 Å
- 6CIN chain E against the predicted model Q2RMD6: TM-score 0.99, RMSD 0.80 Å
- 6CIN chain E against the predicted model Q2RMD6: TM-score 0.99, RMSD 0.80 Å
- 6CIP chain C against the predicted model Q2RMD6: TM-score 0.99, RMSD 0.82 Å
- 6CIP chain C against the predicted model Q2RMD6: TM-score 0.99, RMSD 0.82 Å
Elsewhere
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