UniProt Q15811
Intersectin-1 (Q15811)
Intersectin-1 (UniProt Q15811): 22 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 11 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q15811
- Protein
- Intersectin-1
- Experimental structures
- 22
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 11 · 2 records with a druggable one
Structures
23 records of Q15811 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1KI1 | Guanine Nucleotide Exchange Region of Intersectin in Complex with Cdc42 | x-ray diffraction | B, D | — | — |
| 1KI1 | Guanine nucleotide exchange region of intersectin in complex with CDC42 | x-ray diffraction | B, D | — | — |
| 2KGR | Solution structure of protein ITSN1 from Homo sapiens. Northeast Structural Genomics Consortium… | solution nmr | A | — | — |
| 2KGR | Solution structure of protein ITSN1 from homo sapiens. northeast structural genomics consortium… | solution nmr | A | — | — |
| 2KHN | NMR solution structure of the EH 1 domain from human intersectin-1 protein. Northeast Structural… | solution nmr | A | — | — |
| 2KHN | NMR solution structure of the eh 1 domain from human intersectin-1 protein. northeast structural… | solution nmr | A | — | — |
| 3FIA | Crystal structure of the EH 1 domain from human intersectin-1 protein. Northeast Structural… | x-ray diffraction | A | — | — |
| 3FIA | Crystal structure of the eh 1 domain from human intersectin-1 protein. northeast structural… | x-ray diffraction | A | — | — |
| 3QBV | Structure of designed orthogonal interaction between CDC42 and nucleotide exchange domains of… | x-ray diffraction | B, D | — | — |
| 3QBV | Structure of designed orthogonal interaction between CDC42 and nucleotide exchange domains of… | x-ray diffraction | B, D | — | — |
| 4IIM | Crystal structure of the Second SH3 Domain of ITSN1 bound with a synthetic peptide | x-ray diffraction | A, B | — | — |
| 4IIM | Crystal structure of the second SH3 domain of ITSN1 bound with a synthetic peptide | x-ray diffraction | A, B | — | — |
| 5HZI | Crystal structure of photoinhibitable Intersectin1 containing C450M mutant LOV2 domain | x-ray diffraction | A, B | FMN | — |
| 5HZI | Crystal structure of photoinhibitable INTERSECTIN1 containing C450M mutant LOV2 domain | x-ray diffraction | A, B | — | — |
| 5HZJ | Crystal structure of photoinhibitable Intersectin1 containing wildtype LOV2 domain | x-ray diffraction | A, B | FMN | 10 (best 0.74) |
| 5HZJ | Crystal structure of photoinhibitable INTERSECTIN1 containing wildtype LOV2 domain | x-ray diffraction | A, B | — | — |
| 5HZK | Crystal structure of photoinhibitable Intersectin1 containing wildtype LOV2 domain in complex with… | x-ray diffraction | B, D | FMN | — |
| 5HZK | Crystal structure of photoinhibitable INTERSECTIN1 containing wildtype LOV2 domain in complex with… | x-ray diffraction | B, D | — | — |
| 6GBU | Crystal structure of the second SH3 domain of FCHSD2 (SH3-2) in complex with the fourth SH3 domain… | x-ray diffraction | B, D, F, H | — | — |
| 6GBU | Crystal structure of the second SH3 domain of FCHSD2 (SH3-2) in complex with the fourth SH3 domain… | x-ray diffraction | B, D, F, H | — | — |
| 6H5T | Intersectin SH3A short isoform | x-ray diffraction | A, B | 7PG, CL, ZN | 1 (best 0.66) |
| 6H5T | Intersectin SH3A short isoform | x-ray diffraction | A, B | 7PG, CL, ZN | — |
| Q15811 | AlphaFold monomer V2.0 prediction for intersectin-1 (Q15811) | predicted | A | — | — |
Ligands
Experiment against prediction
- 3QBV chain D against the predicted model Q15811: TM-score 0.98, RMSD 0.86 Å
- 3QBV chain D against the predicted model Q15811: TM-score 0.98, RMSD 0.86 Å
- 1KI1 chain B against the predicted model Q15811: TM-score 0.98, RMSD 1.27 Å
- 1KI1 chain B against the predicted model Q15811: TM-score 0.98, RMSD 1.27 Å
- 3QBV chain B against the predicted model Q15811: TM-score 0.97, RMSD 1.07 Å
- 3QBV chain B against the predicted model Q15811: TM-score 0.97, RMSD 1.07 Å
- 4IIM chain B against the predicted model Q15811: TM-score 0.96, RMSD 0.55 Å
- 4IIM chain B against the predicted model Q15811: TM-score 0.96, RMSD 0.55 Å
- 6GBU chain B against the predicted model Q15811: TM-score 0.94, RMSD 0.80 Å
- 6GBU chain B against the predicted model Q15811: TM-score 0.94, RMSD 0.80 Å
Elsewhere
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