MolNFT v1 · #63725 · protein

Crystal structure of the eh 1 domain from human intersectin-1 protein. northeast structural genomics consortium target HR3646E.

3FIA: “Crystal structure of the eh 1 domain from human intersectin-1 protein. northeast structural genomics…”. X-ray diffraction, 2 ligands (CA, SO4), 1 pocket (best druggability 0.30). MolNFT v1 #63725 on GenesisL1: 3D structure, binding…

PDB: 3FIA
Type: protein
Length: 98 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Intersectin-1
UniProt: Q15811
Ligands: CA, SO4
Pockets: 1 · best druggability 0.30

Structure

x-ray diffraction · 1 distinct chain · 54% helix, 6% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Intersectin-1	protein	98	54% helix, 6% strand	Q15811

Ligands and binding sites

CA · Calcium ion · metal · chains A
SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	52	0.30	0.75	13	empty

Modifications

Observed in the structure: 4 modified (engineered).

Compared structures

3FIA · Crystal structure of the EH 1 domain from human intersectin-1 protein. Northeast… · the same entry in another collection · chain A against A, TM-score 1.00
Q15811 · AlphaFold monomer V2.0 prediction for intersectin-1 (Q15811) · a predicted model of the same protein · chain A against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q15811
Elsewhere: RCSB PDB 3FIA · PDBe 3FIA · UniProt Q15811

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