MolNFT v1 · #121573 · protein
Crystal structure of photoinhibitable INTERSECTIN1 containing C450M mutant LOV2 domain
5HZI · Intersectin-1,NPH1-1,INTERSECTIN-1: “Crystal structure of photoinhibitable INTERSECTIN1 containing C450M mutant LOV2 domain”. X-ray diffraction, 1 ligand (FMN), 10 pockets (best druggability 0.75). MolNFT v1 #121573 on GenesisL1: 3D…
- PDB
- 5HZI
- Type
- protein
- Length
- 952 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Intersectin-1,NPH1-1,INTERSECTIN-1
- UniProt
- Q15811, O49003
- Ligands
- FMN
- Pockets
- 10 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 50% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Intersectin-1,NPH1-1,INTERSECTIN-1 | protein | 476 | 50% helix, 18% strand | Q15811, O49003 |
Ligands and binding sites
- FMN · Flavin mononucleotide · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 556 | 0.75 | 0.82 | 64 | empty |
| 2 | 486 | 0.74 | 0.82 | 52 | FMN |
| 3 | 541 | 0.73 | 0.81 | 61 | empty |
| 4 | 207 | 0.70 | 0.87 | 25 | FMN |
| 5 | 206 | 0.48 | 0.75 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 286 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 5HZI · Crystal structure of photoinhibitable Intersectin1 containing C450M mutant LOV2 domain · the same entry in another collection · chain A against A, TM-score 1.00
- Q15811 · AlphaFold monomer V2.0 prediction for intersectin-1 (Q15811) · a predicted model of the same protein · chain A against A, TM-score 0.46
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15811
- Every structure of UniProt O49003
- Elsewhere: RCSB PDB 5HZI · PDBe 5HZI · UniProt Q15811 · UniProt O49003
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