UniProt Q14790
Caspase-8 (Q14790)
Caspase-8 (UniProt Q14790), EC 3.4.22.61: 50 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 105 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q14790
- Protein
- Caspase-8
- EC
- 3.4.22.61
- Experimental structures
- 50
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 105 · 9 records with a druggable one
Structures
51 records of Q14790 in the MolNFT archive: 50 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1F9E | Caspase-8 specificity probed at subsite S4: crystal structure of the caspase-8-Z-devd-cho | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 1F9E | Caspase-8 specificity probed at subsite S4: crystal structure of the caspase-8-Z-devd-cho | x-ray diffraction | B, D, F, J, L | — | — |
| 1I4E | Crystal structure of the caspase-8/P35 complex | x-ray diffraction | B | — | — |
| 1I4E | Crystal structure of the caspase-8/P35 complex | x-ray diffraction | B | — | — |
| 1QDU | Crystal structure of the complex of caspase-8 with the tripeptide ketone inhibitor zevd-dcbmk | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 1QDU | Crystal structure of the complex of caspase-8 with the tripeptide ketone inhibitor zevd-dcbmk | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 1QTN | Crystal structure of the complex of caspase-8 with the tetrapeptide inhibitor ACE-ietd-aldehyde | x-ray diffraction | A, B | — | — |
| 1QTN | Crystal structure of the complex of caspase-8 with the tetrapeptide inhibitor ACE-ietd-aldehyde | x-ray diffraction | A, B | — | — |
| 2C2Z | Crystal structure of caspase-8 in complex with aza-peptide Michael acceptor inhibitor | x-ray diffraction | A, B | — | — |
| 2C2Z | Crystal structure of caspase-8 in complex with aza-peptide michael acceptor inhibitor | x-ray diffraction | A, B | — | — |
| 2FUN | alternative p35-caspase-8 complex | x-ray diffraction | B, D | — | — |
| 2FUN | Alternative P35-caspase-8 complex | x-ray diffraction | B, D | — | — |
| 2K7Z | Solution Structure of the Catalytic Domain of Procaspase-8 | solution nmr | A | — | — |
| 2K7Z | Solution structure of the catalytic domain of procaspase-8 | solution nmr | A | — | — |
| 2Y1L | Caspase-8 in Complex with DARPin-8.4 | x-ray diffraction | A, B, C, D | — | — |
| 2Y1L | Caspase-8 in complex with darpin-8.4 | x-ray diffraction | A, B, C, D | — | — |
| 3H11 | Zymogen caspase-8:c-FLIPL protease domain complex | x-ray diffraction | B | — | — |
| 3H11 | Zymogen caspase-8:C-flipl protease domain complex | x-ray diffraction | B | — | — |
| 3KJN | Caspase 8 bound to a covalent inhibitor | x-ray diffraction | A, B | — | — |
| 3KJN | Caspase 8 bound to a covalent inhibitor | x-ray diffraction | A, B | — | — |
| 3KJQ | Caspase 8 with covalent inhibitor | x-ray diffraction | A, B | — | — |
| 3KJQ | Caspase 8 with covalent inhibitor | x-ray diffraction | A, B | — | — |
| 4JJ7 | Caspase-3 specific unnatural amino acid-based peptides | x-ray diffraction | A | — | — |
| 4JJ7 | Caspase-3 specific unnatural amino acid-based peptides | x-ray diffraction | A | — | — |
| 4PRZ | Caspase-8 specific unnatural amino acid peptides | x-ray diffraction | A | — | — |
| 4PRZ | Caspase-8 specific unnatural amino acid peptides | x-ray diffraction | A | — | — |
| 4PS1 | Caspase-8 specific unnatural amino acid peptides | x-ray diffraction | A, B, C, D | — | — |
| 4PS1 | Caspase-8 specific unnatural amino acid peptides | x-ray diffraction | A, B, C, D | — | — |
| 4ZBW | Crystal structure of death effector domain of Caspase8 in Homo Sapiens | x-ray diffraction | A, B | — | — |
| 4ZBW | Crystal structure of death effector domain of CASPASE8 in homo sapiens | x-ray diffraction | A, B | — | — |
| 5H31 | Structural basis for dimerization of the death effector domains of Caspase-8 | x-ray diffraction | A, B, C, D | — | — |
| 5H31 | Structural basis for dimerization of the death effector domains of caspase-8 | x-ray diffraction | A, B, C, D | — | — |
| 5H33 | Structural basis for dimerization of the death effector domains of Caspase-8 | x-ray diffraction | A, B | — | 7 (best 0.52) |
| 5H33 | Structural basis for dimerization of the death effector domains of caspase-8 | x-ray diffraction | A, B | — | — |
| 5JQE | Crystal structure of caspase8 tDED | x-ray diffraction | A | — | — |
| 5JQE | Crystal structure of CASPASE8 tded | x-ray diffraction | A | — | — |
| 5L08 | Cryo-EM structure of Casp-8 tDED filament | electron microscopy | A, B, C, D, E, F, G, H, I | — | — |
| 5L08 | Cryo-EM structure of casp-8 tded filament | electron microscopy | A, B, C, D, E, F, G, H, I | — | — |
| 6AGW | Pro-domain of caspase-8 | x-ray diffraction | A | — | — |
| 6PX9 | Crystal structure of procaspase-8 in complex with covalent small molecule inhibitor 63-R | x-ray diffraction | A, B, C, D, E, F | 63R | 8 (best 0.70) |
| 6PX9 | Crystal structure of procaspase-8 in complex with covalent small molecule inhibitor 63-R | x-ray diffraction | A, B, C, D, E, F | 63R | — |
| 6X8H | Caspase-8 in complex with aomk inhibitor, ac-DW3-ke, forms tetrahedral adduct | x-ray diffraction | A, B | ACE, Y1Y | — |
| 7LVM | CASP8 isoform B ded domain | x-ray diffraction | A | — | — |
| 8YD7 | Structure of FADD/Caspase-8/cFLIP death effector domain assembly | x-ray diffraction | D, C, B, E, A | — | 18 (best 0.78) |
| 8YD8 | Structure of FADD/Caspase-8/cFLIP death effector domain assembly | x-ray diffraction | D, C, B, E, A | — | 18 (best 0.83) |
| 8YM6 | Structure of Caspase-8/cFLIP death effector domain assembly | x-ray diffraction | C, B, A, D | — | 8 (best 0.78) |
| 8YNI | Structure of the FADD/Caspase-8/cFLIP death effector domain assembly | electron microscopy | A, B, C | — | 12 (best 0.76) |
| 8YNL | Structure of the Caspase-8/cFLIP death effector domain assembly | electron microscopy | A, B, C | — | 11 (best 0.74) |
| 8YNM | Structure of the Caspase-8/cFLIP death effector domain assembly | electron microscopy | A, B, C | — | 9 (best 0.74) |
| 8YNN | Structure of the Caspase-8/cFLIP death effector domain assembly | electron microscopy | A, B, C | — | 14 (best 0.75) |
| Q14790 | AlphaFold monomer V2.0 prediction for caspase-8 (Q14790) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4PS1 chain C against the predicted model Q14790: TM-score 1.00, RMSD 0.30 Å
- 4PS1 chain C against the predicted model Q14790: TM-score 1.00, RMSD 0.30 Å
- 4PRZ chain A against the predicted model Q14790: TM-score 1.00, RMSD 0.32 Å
- 4PRZ chain A against the predicted model Q14790: TM-score 1.00, RMSD 0.32 Å
- 2C2Z chain A against the predicted model Q14790: TM-score 1.00, RMSD 0.25 Å
- 2C2Z chain A against the predicted model Q14790: TM-score 1.00, RMSD 0.25 Å
- 4PS1 chain A against the predicted model Q14790: TM-score 1.00, RMSD 0.32 Å
- 4PS1 chain A against the predicted model Q14790: TM-score 1.00, RMSD 0.32 Å
- 4PS1 chain B against the predicted model Q14790: TM-score 1.00, RMSD 0.33 Å
- 4PS1 chain B against the predicted model Q14790: TM-score 1.00, RMSD 0.33 Å
Elsewhere
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