MolNFT v1 · #142830 · protein

Pro-domain of caspase-8

6AGW · Caspase-8 pro-domain: “Pro-domain of caspase-8”. X-ray diffraction, 1 pocket (best druggability 0.39). MolNFT v1 #142830 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6AGW
Type: protein
Length: 179 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Caspase-8 pro-domain
EC: 3.4.22.61
UniProt: Q14790
Pockets: 1 · best druggability 0.39

Structure

x-ray diffraction · 1 distinct chain · 63% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Caspase-8 pro-domain (EC 3.4.22.61)	protein	179	63% helix, 2% strand	Q14790

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	119	0.39	0.74	20	empty

Compared structures

6AGW · Pro-domain of Caspase-8 · the same entry in another collection · chain A against A, TM-score 1.00
Q14790 · AlphaFold monomer V2.0 prediction for caspase-8 (Q14790) · a predicted model of the same protein · chain A against A, TM-score 0.69

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q14790
Elsewhere: RCSB PDB 6AGW · PDBe 6AGW · UniProt Q14790

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