MolNFT v1 · #125141 · protein
Cryo-EM structure of casp-8 tded filament
5L08 · Caspase-8: “Cryo-EM structure of casp-8 tded filament”. Electron microscopy, 20 pockets (best druggability 0.80). MolNFT v1 #125141 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5L08
- Type
- protein
- Length
- 1,629 residues
- Chains
- 9
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Caspase-8
- EC
- 3.4.22.61
- UniProt
- Q14790
- Pockets
- 20 · best druggability 0.80
Structure
electron microscopy · 1 distinct chain · 62% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I | Caspase-8 (EC 3.4.22.61) | protein | 181 | 62% helix, 1% strand | Q14790 |
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 933 | 0.80 | 0.82 | 123 | empty |
| 2 | 1082 | 0.80 | 0.81 | 109 | empty |
| 3 | 654 | 0.76 | 0.81 | 66 | empty |
| 4 | 669 | 0.72 | 0.79 | 66 | empty |
| 5 | 50 | 0.72 | 0.98 | 14 | empty |
Interfaces
19 interfaces between chains.
- A–H · 908 Ų buried · 18 hydrogen bonds · protein-protein
- B–I · 852 Ų buried · 18 hydrogen bonds · protein-protein
- F–H · 798 Ų buried · 17 hydrogen bonds · protein-protein
- E–G · 758 Ų buried · 15 hydrogen bonds · protein-protein
- C–F · 745 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14790
- Elsewhere: RCSB PDB 5L08 · PDBe 5L08 · UniProt Q14790
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