UniProt Q13563
Polycystin-2 (Q13563)
Polycystin-2 (UniProt Q13563): 32 experimental structures on GenesisL1, 8 ligands bound, 118 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q13563
- Protein
- Polycystin-2
- Experimental structures
- 32
- Predicted models
- 0
- Ligands
- 8
- Pockets
- 118 · 6 records with a druggable one
Structures
32 records of Q13563 in the MolNFT archive: 32 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2KLD | Solution Structure of the Calcium Binding Domain of the C-terminal Cytosolic Domain of Polycystin-2 | solution nmr | A | — | — |
| 2KLD | Solution structure of the calcium binding domain of the C-terminal cytosolic domain of polycystin-2 | solution nmr | A | — | — |
| 2KLE | ISIC Refined Solution Structure of the Calcium Binding Domain of the C-terminal Cytosolic Domain of… | solution nmr | A | — | — |
| 2KLE | Isic refined solution structure of the calcium binding domain of the C-terminal cytosolic domain of… | solution nmr | A | — | — |
| 2KQ6 | The structure of the EF-hand domain of polycystin-2 suggests a mechanism for Ca2+-dependent… | solution nmr | A | — | — |
| 2KQ6 | The structure of the ef-hand domain of polycystin-2 suggests a mechanism for CA2+-dependent… | solution nmr | A | — | — |
| 2Y4Q | Solution structure of the EF-hand domain of Human Polycystin 2 | solution nmr | A | — | — |
| 2Y4Q | Solution structure of the ef-hand domain of human polycystin 2 | solution nmr | A | — | — |
| 3HRN | crystal structure of a C-terminal coiled coil domain of Transient receptor potential (TRP) channel… | x-ray diffraction | A | — | — |
| 3HRN | Crystal structure of a C-terminal coiled coil domain of transient receptor potential (TRP) channel… | x-ray diffraction | A | — | — |
| 3HRO | Crystal structure of a C-terminal coiled coil domain of Transient receptor potential (TRP) channel… | x-ray diffraction | A | — | — |
| 3HRO | Crystal structure of a C-terminal coiled coil domain of transient receptor potential (TRP) channel… | x-ray diffraction | A | — | — |
| 5K47 | CryoEM structure of the human Polycystin-2/PKD2 TRP channel | electron microscopy | A, B, C, D | NAG | — |
| 5K47 | Cryoem structure of the human polycystin-2/PKD2 TRP channel | electron microscopy | A, B, C, D | NAG | — |
| 5MKE | cryoEM Structure of Polycystin-2 in complex with cations and lipids | electron microscopy | A, B, C, D | NAG, PX6, PLM | — |
| 5MKE | Cryoem structure of polycystin-2 in complex with cations and lipids | electron microscopy | A, B, C, D | NAG, PX6, PLM | — |
| 5MKF | cryoEM Structure of Polycystin-2 in complex with calcium and lipids | electron microscopy | A, B, C, D | NAG, PX6, PLM, CA | — |
| 5MKF | Cryoem structure of polycystin-2 in complex with calcium and lipids | electron microscopy | A, B, C, D | NAG, PX6, PLM, CA | — |
| 5T4D | Cryo-EM structure of Polycystic Kidney Disease protein 2 (PKD2), residues 198-703 | electron microscopy | A, B, C, D | NAG | 20 (best 0.87) |
| 5T4D | Cryo-EM structure of polycystic kidney disease protein 2 (PKD2), residues 198-703 | electron microscopy | A, B, C, D | NAG | — |
| 6A70 | Structure of the human PKD1/PKD2 complex | electron microscopy | A, F, G | — | 18 (best 0.85) |
| 6A70 | Structure of the human PKD1/PKD2 complex | electron microscopy | A, F, G | — | — |
| 6D1W | human PKD2 F604P mutant | electron microscopy | A, B, C, D | NAG | — |
| 6D1W | Human PKD2 F604P mutant | electron microscopy | A, B, C, D | NAG | — |
| 6T9N | CryoEM structure of human polycystin-2/PKD2 in UDM supplemented with PI(4,5)P2 | electron microscopy | A, B, C, D | NAG, CLR, UMQ, CA | 20 (best 0.84) |
| 6T9N | Cryoem structure of human polycystin-2/PKD2 in udm supplemented with PI(4,5)P2 | electron microscopy | A, B, C, D | NAG, CLR, UMQ, CA | — |
| 6T9O | Cryoem structure of human polycystin-2/PKD2 in udm supplemented with PI(3,5)P2 | electron microscopy | A, B, C, D | NAG, CLR, UMQ, CA | — |
| 6WB8 | Cryo-EM structure of PKD2 C331S disease variant | electron microscopy | A, B, C, D | NAG | 20 (best 0.87) |
| 6WB8 | Cryo-EM structure of PKD2 C331S disease variant | electron microscopy | A, B, C, D | NAG | — |
| 8HK7 | Structure of PKD2-F604P (Polycystin-2, TRPP2) with ML-SA1 | electron microscopy | A, B, C, D | NAG, CA, AQV | 20 (best 0.86) |
| 8K3S | Structure of PKD2-F604P complex | electron microscopy | A, B, C, D | PEF, NAG, CA | 20 (best 0.85) |
| Q13563 | AlphaFold monomer V2.0 prediction for polycystin-2 (Q13563) | — | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 17 records
- CA · Calcium ion · in 7 records
- PLM · Palmitic acid · in 4 records
- PX6 · 1,2-dipalmitoyl-sn-glycero-3-phosphate · in 4 records
- CLR · Cholesterol · in 3 records
- UMQ · Undecyl-maltoside · in 3 records
- AQV · 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione · in 1 record
- PEF · Di-palmitoyl-3-sn-phosphatidylethanolamine · in 1 record
Elsewhere
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