UniProt Q13315
Serine-protein kinase ATM (Q13315)
Serine-protein kinase ATM (UniProt Q13315), EC 2.7.11.1: 15 experimental structures on GenesisL1, 6 ligands bound, 60 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q13315
- Protein
- Serine-protein kinase ATM
- EC
- 2.7.11.1
- Experimental structures
- 15
- Predicted models
- 0
- Ligands
- 6
- Pockets
- 60 · 3 records with a druggable one
Structures
15 records of Q13315 in the MolNFT archive: 15 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5NP0 | Closed dimer of human ATM (Ataxia telangiectasia mutated) | electron microscopy | A, B | — | — |
| 5NP0 | Closed dimer of human atm (ataxia telangiectasia mutated) | electron microscopy | A, B | — | — |
| 5NP1 | Open protomer of human ATM (Ataxia telangiectasia mutated) | electron microscopy | A | — | — |
| 5NP1 | Open protomer of human atm (ataxia telangiectasia mutated) | electron microscopy | A | — | — |
| 6HKA | The solution structure of the micelle-associated fatc domain of the human protein kinase ataxia… | solution nmr | A | — | — |
| 6K9K | Monomeric human ATM (Ataxia telangiectasia mutated) kinase | electron microscopy | A | — | 20 (best 0.90) |
| 6K9K | Monomeric human atm (ataxia telangiectasia mutated) kinase | electron microscopy | A | — | — |
| 6K9L | 4.27 Angstrom resolution cryo-EM structure of human dimeric ATM kinase | electron microscopy | A, B | — | 20 (best 0.84) |
| 6K9L | 4.27 ångström resolution cryo-EM structure of human dimeric atm kinase | electron microscopy | A, B | — | — |
| 7NI4 | Human atm kinase domain with bound M4076 inhibitor | electron microscopy | A, B | ZN, UGK | — |
| 7NI5 | Human atm kinase with bound inhibitor ku-55933 | electron microscopy | A, B | UF8, ZN | — |
| 7NI6 | Human atm kinase with bound atpys | electron microscopy | A, B | ZN, AGS, MG | — |
| 7SIC | Human atm dimer | electron microscopy | A, B | ANP, MG | — |
| 7SID | Human atm dimer bound to NBS1 | electron microscopy | A, C | ANP, MG | — |
| 8OXO | ATM(Q2971A) dimeric C-terminal region activated by oxidative stress in complex with Mg AMP-PNP and… | electron microscopy | A, B | ANP, MG, ZN | 20 (best 0.80) |
Ligands
- MG · Magnesium ion · in 4 records
- ZN · Zinc ion · in 4 records
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 3 records
- AGS · Phosphothiophosphoric acid-adenylate ester · in 1 record
- UF8 · 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one · in 1 record
- UGK · 8-(1,3-dimethylpyrazol-4-yl)-1-(3-fluoranyl-5-methoxy-pyridin-4-yl)-7-methoxy-3-methyl-imidazo[4,5-c]quinolin-2-one · in 1 record
Experiment against prediction
- 6HKA chain A against the predicted model P19909: TM-score 0.48, RMSD 2.30 Å
Elsewhere
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