MolNFT v1 · #154388 · protein

4.27 ångström resolution cryo-EM structure of human dimeric atm kinase

6K9L · Serine-protein kinase atm: “4.27 ångström resolution cryo-EM structure of human dimeric atm kinase”. Electron microscopy, 20 pockets (best druggability 0.84). MolNFT v1 #154388 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 6K9L
Type: protein
Length: 5,103 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Serine-protein kinase atm
EC: 2.7.11.1
UniProt: Q13315
Pockets: 20 · best druggability 0.84

Structure

electron microscopy · 2 distinct chains · 57% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Serine-protein kinase atm (EC 2.7.11.1)	protein	2552	57% helix, 2% strand	Q13315
B	Serine-protein kinase atm (EC 2.7.11.1)	protein	2551	56% helix, 2% strand	Q13315

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1118	0.84	0.85	155	empty
2	781	0.84	0.87	111	empty
3	1164	0.84	0.85	120	empty
4	1040	0.83	0.84	134	empty
5	827	0.82	0.85	101	empty

Interfaces

1 interface between chains.

A–B · 3007 Å² buried · 31 hydrogen bonds · protein-protein

Compared structures

6K9L · 4.27 Angstrom resolution cryo-EM structure of human dimeric ATM kinase · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13315
Elsewhere: RCSB PDB 6K9L · PDBe 6K9L · UniProt Q13315

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