MolNFT v1 · #187525 · protein

Human atm dimer

7SIC · Serine-protein kinase atm: “Human atm dimer”. Electron microscopy, 2 ligands (ANP, MG), 20 pockets (best druggability 0.85). MolNFT v1 #187525 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7SIC
Type: protein
Length: 5,546 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Serine-protein kinase atm
EC: 2.7.11.1
UniProt: Q13315
Ligands: ANP, MG
Pockets: 20 · best druggability 0.85

Structure

electron microscopy · 1 distinct chain · 67% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Serine-protein kinase atm (EC 2.7.11.1)	protein	2773	67% helix, 2% strand	Q13315

Ligands and binding sites

ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · 2 copies · chains A, B
MG · Magnesium ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	969	0.85	0.86	99	empty
2	851	0.83	0.85	83	empty
3	966	0.80	0.81	130	empty
4	966	0.78	0.80	96	empty
5	949	0.78	0.80	89	empty

Interfaces

1 interface between chains.

A–B · 4014 Å² buried · 22 hydrogen bonds · protein-protein

Compared structures

7SIC · Human ATM Dimer · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13315
Elsewhere: RCSB PDB 7SIC · PDBe 7SIC · UniProt Q13315

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