UniProt Q12417
Pre-mRNA-splicing factor PRP46 (Q12417)
Pre-mRNA-splicing factor PRP46 (UniProt Q12417): 23 experimental structures and 1 predicted model on GenesisL1, 26 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q12417
- Protein
- Pre-mRNA-splicing factor PRP46
- Experimental structures
- 23
- Predicted models
- 1
- Pockets
- 26 · 6 records with a druggable one
Structures
24 records of Q12417 in the MolNFT archive: 23 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5GMK | Cryo-EM structure of the catalytic step I spliceosome (C complex) at 3.4 ångström resolution | electron microscopy | O | — | — |
| 5LJ5 | Overall structure of the yeast spliceosome immediately after branching. | electron microscopy | J | — | — |
| 5LQW | yeast activated spliceosome | electron microscopy | K | — | — |
| 5LQW | Yeast activated spliceosome | electron microscopy | K | — | — |
| 5MPS | Structure of a spliceosome remodeled for exon ligation | electron microscopy | J | — | — |
| 5MQ0 | Structure of a spliceosome remodeled for exon ligation | electron microscopy | J | — | 5 (best 0.87) |
| 5MQ0 | Structure of a spliceosome remodeled for exon ligation | electron microscopy | J | — | — |
| 5WSG | Cryo-EM structure of the Catalytic Step II spliceosome (C* complex) at 4.0 angstrom resolution | electron microscopy | O | — | — |
| 5WSG | Cryo-EM structure of the catalytic step II spliceosome (C* complex) at 4.0 ångström resolution | electron microscopy | O | — | — |
| 5Y88 | Cryo-EM structure of the intron-lariat spliceosome ready for disassembly from S.CEREVISIAE at 3.5… | electron microscopy | O | — | — |
| 5YLZ | Cryo-EM Structure of the Post-catalytic Spliceosome from Saccharomyces cerevisiae at 3.6 angstrom | electron microscopy | O | — | — |
| 5YLZ | Cryo-EM structure of the post-catalytic spliceosome from saccharomyces cerevisiae at 3.6 ångström | electron microscopy | O | — | — |
| 6BK8 | S. cerevisiae spliceosomal post-catalytic P complex | electron microscopy | D | — | — |
| 6EXN | Post-catalytic P complex spliceosome with 3' splice site docked | electron microscopy | J | — | — |
| 6EXN | Post-catalytic P complex spliceosome with 3' splice site docked | electron microscopy | J | — | — |
| 6J6G | Cryo-EM structure of the yeast B*-a2 complex at an average resolution of 3.2 angstrom | electron microscopy | O | — | 6 (best 0.86) |
| 6J6G | Cryo-EM structure of the yeast B*-A2 complex at an average resolution of 3.2 ångström | electron microscopy | O | — | — |
| 6J6H | Cryo-EM structure of the yeast B*-a1 complex at an average resolution of 3.6 angstrom | electron microscopy | O | — | 3 (best 0.88) |
| 6J6H | Cryo-EM structure of the yeast B*-A1 complex at an average resolution of 3.6 ångström | electron microscopy | O | — | — |
| 6J6N | Cryo-EM structure of the yeast B*-b1 complex at an average resolution of 3.86 angstrom | electron microscopy | O | — | 4 (best 0.88) |
| 6J6N | Cryo-EM structure of the yeast B*-B1 complex at an average resolution of 3.86 ångström | electron microscopy | O | — | — |
| 6J6Q | Cryo-EM structure of the yeast B*-b2 complex at an average resolution of 3.7 angstrom | electron microscopy | O | — | 5 (best 0.85) |
| 6J6Q | Cryo-EM structure of the yeast B*-B2 complex at an average resolution of 3.7 ångström | electron microscopy | O | — | — |
| Q12417 | AlphaFold monomer V2.0 prediction for pre-mRNA-splicing factor PRP46 (Q12417) | predicted | A | — | 3 (best 0.79) |
Experiment against prediction
- 5Y88 chain O against the predicted model Q12417: TM-score 0.98, RMSD 1.10 Å
- 5YLZ chain O against the predicted model Q12417: TM-score 0.98, RMSD 1.14 Å
- 5YLZ chain O against the predicted model Q12417: TM-score 0.98, RMSD 1.14 Å
- 5LJ5 chain J against the predicted model Q12417: TM-score 0.98, RMSD 1.18 Å
- 5GMK chain O against the predicted model Q12417: TM-score 0.98, RMSD 1.17 Å
- 5WSG chain O against the predicted model Q12417: TM-score 0.97, RMSD 1.19 Å
- 5WSG chain O against the predicted model Q12417: TM-score 0.97, RMSD 1.19 Å
- 6EXN chain J against the predicted model Q12417: TM-score 0.97, RMSD 1.44 Å
- 6EXN chain J against the predicted model Q12417: TM-score 0.97, RMSD 1.44 Å
- 5LQW chain K against the predicted model Q12417: TM-score 0.97, RMSD 1.24 Å
Elsewhere
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