UniProt Q12200
NPC intracellular sterol transporter 1-related protein 1 (Q12200)
NPC intracellular sterol transporter 1-related protein 1 (UniProt Q12200): 6 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 93 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q12200
- Protein
- NPC intracellular sterol transporter 1-related protein 1
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 93 · 6 records with a druggable one
Structures
7 records of Q12200 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6R4L | Crystal structure of S. cerevisia Niemann-Pick type C protein NCR1 | x-ray diffraction | A | NAG, ERG | 20 (best 0.86) |
| 6R4L | Crystal structure of S. cerevisia niemann-pick type C protein NCR1 | x-ray diffraction | A | NAG, ERG | — |
| 8QEB | S. cerevisia Niemann-Pick type C protein NCR1 in GDN at pH 7.5 | electron microscopy | A | NAG, Y01, ERG | 13 (best 0.88) |
| 8QEC | S. cerevisia Niemann-Pick type C protein NCR1 in GDN at pH 5.5 | electron microscopy | A | NAG, Y01, ERG, Q7G | 16 (best 0.87) |
| 8QED | S. cerevisia Niemann-Pick type C protein NCR1 in LMNG at pH 5.5 | electron microscopy | A | NAG, ERG, PTY | 15 (best 0.86) |
| 9F41 | Crystal structure of the NTD domain from S. cerevisia Niemann-Pick type C protein NCR1 with… | x-ray diffraction | A, B, C, D | NAG, BMA, MAN, CLR, ZN, SO4 | 13 (best 0.76) |
| Q12200 | AlphaFold monomer V2.0 prediction for npc intracellular sterol transporter 1-related protein 1… | predicted | A | — | 16 (best 0.88) |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 6 records
- ERG · Ergosterol · in 5 records
- Y01 · Cholesterol hemisuccinate · in 2 records
- BMA · beta-D-mannopyranose · in 1 record
- CLR · Cholesterol · in 1 record
- MAN · alpha-D-mannopyranose · in 1 record
- PTY · Phosphatidylethanolamine · in 1 record
- Q7G · 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta, 17beta,25r)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside · in 1 record
- SO4 · Sulfate ion · in 1 record
- ZN · Zinc ion · in 1 record
Experiment against prediction
- 9F41 chain A against the predicted model Q12200: TM-score 0.96, RMSD 1.21 Å
- 9F41 chain D against the predicted model Q12200: TM-score 0.96, RMSD 1.26 Å
- 9F41 chain B against the predicted model Q12200: TM-score 0.96, RMSD 1.23 Å
- 9F41 chain C against the predicted model Q12200: TM-score 0.96, RMSD 1.26 Å
- 6R4L chain A against the predicted model Q12200: TM-score 0.87, RMSD 4.23 Å
- 6R4L chain A against the predicted model Q12200: TM-score 0.87, RMSD 4.23 Å
- 8QED chain A against the predicted model Q12200: TM-score 0.85, RMSD 4.02 Å
- 8QEB chain A against the predicted model Q12200: TM-score 0.85, RMSD 4.42 Å
- 8QEC chain A against the predicted model Q12200: TM-score 0.84, RMSD 4.16 Å
Elsewhere
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