UniProt Q10471
Galnac-T2 (Q10471)
Galnac-T2 (UniProt Q10471), EC 2.4.1.41: 25 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 33 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q10471
- Protein
- Galnac-T2
- EC
- 2.4.1.41
- Experimental structures
- 25
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 33 · 3 records with a druggable one
Structures
26 records of Q10471 in the MolNFT archive: 25 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2FFU | Crystal Structure of Human ppGalNAcT-2 complexed with UDP and EA2 | x-ray diffraction | A | — | — |
| 2FFU | Crystal structure of human ppgalnact-2 complexed with udp and EA2 | x-ray diffraction | A | — | — |
| 2FFV | Human ppGalNAcT-2 complexed with manganese and UDP | x-ray diffraction | A, B | — | — |
| 2FFV | Human ppgalnact-2 complexed with manganese and udp | x-ray diffraction | A, B | — | — |
| 4D0T | GalNAc-T2 crystal soaked with UDP-GalNAc, EA2 peptide and manganese | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4D0T | Galnac-T2 crystal soaked with udp-galnac, EA2 peptide and manganese | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4D0Z | GalNAc-T2 crystal soaked with UDP-5SGalNAc, mEA2 and manganese (Higher resolution dataset) | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4D0Z | Galnac-T2 crystal soaked with udp-5SGALNAC, MEA2 and manganese (higher resolution dataset) | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4D11 | GalNAc-T2 crystal soaked with UDP-5SGalNAc, mEA2 peptide and manganese (Lower resolution dataset) | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4D11 | Galnac-T2 crystal soaked with udp-5SGALNAC, MEA2 peptide and manganese (lower resolution dataset) | x-ray diffraction | A, B, C, D, E, F | — | — |
| 5AJN | Crystal structure of the inactive form of GalNAc-T2 in complex with the glycopeptide MUC5AC-Cys13 | x-ray diffraction | A | — | — |
| 5AJN | Crystal structure of the inactive form of galnac-T2 in complex with the glycopeptide MUC5AC-CYS13 | x-ray diffraction | A | — | — |
| 5AJO | Crystal structure of the inactive form of GalNAc-T2 in complex with the glycopeptide MUC5AC-3,13 | x-ray diffraction | A | — | — |
| 5AJO | Crystal structure of the inactive form of galnac-T2 in complex with the glycopeptide MUC5AC-3,13 | x-ray diffraction | A | — | — |
| 5AJP | Crystal structure of the active form of GalNAc-T2 in complex with UDP and the glycopeptide MUC5AC-13 | x-ray diffraction | A | — | — |
| 5AJP | Crystal structure of the active form of galnac-T2 in complex with udp and the glycopeptide MUC5AC-13 | x-ray diffraction | A | — | — |
| 5FV9 | Crystal structure of GalNAc-T2 in complex with compound 16d | x-ray diffraction | A, B, C, D, E, F | UDP, MN, Y6W | 20 (best 0.82) |
| 5FV9 | Crystal structure of galnac-T2 in complex with compound 16D | x-ray diffraction | A, B, C, D, E, F | — | — |
| 5NDF | Small-molecule inhibition of ppGalNAc-Ts selectively reduces mucin-type O-glycosylation | x-ray diffraction | A, B, C, D, E, F | MN, UDP, LU2 | — |
| 5NDF | Small-molecule inhibition of ppgalnac-ts selectively reduces mucin- type O-glycosylation | x-ray diffraction | A, B, C, D, E, F | MN, UDP, LU2 | — |
| 6E7I | Human ppGalNAcT2 I253A/L310A Mutant with EA2 and UDP | x-ray diffraction | A | UDP, MN | 4 (best 0.84) |
| 6E7I | Human PPGALNACT2 I253A/L310A mutant with EA2 and udp | x-ray diffraction | A | UDP, MN | — |
| 6EGS | Crystal structure of the GalNAc-T2 F104S mutant in complex with UDP-GalNAc | x-ray diffraction | A, B | MN, UD2 | 9 (best 0.83) |
| 6EGS | Crystal structure of the galnac-T2 F104S mutant in complex with udp- galnac | x-ray diffraction | A, B | MN, UD2 | — |
| 6NQT | Galnac-T2 soaked with udp-sugar | x-ray diffraction | A, B, C, D, E, F | MN, LR7 | — |
| Q10471 | AlphaFold monomer V2.0 prediction for polypeptide N-acetylgalactosaminyltransferase 2 (Q10471) | predicted | A | — | — |
Ligands
- MN · Manganese (II) ion · in 8 records
- UDP · Uridine-5'-diphosphate · in 5 records
- LU2 · 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one · in 2 records
- UD2 · Uridine-diphosphate-N-acetylgalactosamine · in 2 records
- LR7 · [[(2~{R},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene) pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R},6~{R})-3-(hex-5-ynoylamino)-6-(hydroxymethyl)-4,5-bis(oxidanyl)oxan-2-yl] hydrogen phosphate · in 1 record
- Y6W · [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl hydrogen (S)-{3-[(2R,3R,4R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]propyl}phosphonate · in 1 record
Experiment against prediction
- 4D11 chain F against the predicted model Q10471: TM-score 0.99, RMSD 0.56 Å
- 4D11 chain F against the predicted model Q10471: TM-score 0.99, RMSD 0.56 Å
- 5AJP chain A against the predicted model Q10471: TM-score 0.99, RMSD 0.77 Å
- 5AJP chain A against the predicted model Q10471: TM-score 0.99, RMSD 0.77 Å
- 5NDF chain A against the predicted model Q10471: TM-score 0.98, RMSD 1.04 Å
- 5NDF chain A against the predicted model Q10471: TM-score 0.98, RMSD 1.04 Å
- 5NDF chain B against the predicted model Q10471: TM-score 0.98, RMSD 1.10 Å
- 5NDF chain B against the predicted model Q10471: TM-score 0.98, RMSD 1.10 Å
- 4D0T chain B against the predicted model Q10471: TM-score 0.98, RMSD 1.12 Å
- 4D0T chain B against the predicted model Q10471: TM-score 0.98, RMSD 1.12 Å
Elsewhere
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