UniProt Q07812
Apoptosis regulator BAX (Q07812)
Apoptosis regulator BAX (UniProt Q07812): 62 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 53 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q07812
- Protein
- Apoptosis regulator BAX
- Experimental structures
- 62
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 53 · 8 records with a druggable one
Structures
63 records of Q07812 in the MolNFT archive: 62 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1F16 | Solution structure of a pro-apoptotic protein bax | solution nmr | A | — | — |
| 1F16 | Solution structure of a pro-apoptotic protein bax | solution nmr | A | — | — |
| 2K7W | BAX Activation is Initiated at a Novel Interaction Site | solution nmr | A | — | — |
| 2K7W | Bax activation is initiated at a novel interaction site | solution nmr | A | — | — |
| 2LR1 | Structural Mechanism for Bax Inhibition by Cytomegalovirus Protein vMIA | solution nmr | A | — | — |
| 2LR1 | Structural mechanism for bax inhibition by cytomegalovirus protein vmia | solution nmr | A | — | — |
| 3PK1 | Crystal structure of Mcl-1 in complex with the BaxBH3 domain | x-ray diffraction | B, D | — | — |
| 3PK1 | Crystal structure of mcl-1 in complex with the BAXBH3 domain | x-ray diffraction | B, D | — | — |
| 3PL7 | Crystal structure of Bcl-xL in complex with the BaxBH3 domain | x-ray diffraction | C | — | — |
| 3PL7 | Crystal structure of BCL-xl in complex with the BAXBH3 domain | x-ray diffraction | C | — | — |
| 4BD2 | Bax domain swapped dimer in complex with BidBH3 | x-ray diffraction | A | — | — |
| 4BD2 | Bax domain swapped dimer in complex with BIDBH3 | x-ray diffraction | A | — | — |
| 4BD6 | Bax domain swapped dimer in complex with BaxBH3 | x-ray diffraction | A, C | — | — |
| 4BD6 | Bax domain swapped dimer in complex with BAXBH3 | x-ray diffraction | A, C | — | — |
| 4BD7 | Bax domain swapped dimer induced by octylmaltoside | x-ray diffraction | A, B, C, D | — | — |
| 4BD7 | Bax domain swapped dimer induced by octylmaltoside | x-ray diffraction | A, B, C, D | — | — |
| 4BD8 | Bax domain swapped dimer induced by BimBH3 with CHAPS | x-ray diffraction | A, B, C, D | — | — |
| 4BD8 | Bax domain swapped dimer induced by BIMBH3 with chaps | x-ray diffraction | A, B, C, D | — | — |
| 4BDU | Bax BH3-in-Groove dimer (GFP) | x-ray diffraction | A, B, C, D | — | — |
| 4BDU | Bax BH3-in-groove dimer (GFP) | x-ray diffraction | A, B, C, D | — | — |
| 4S0O | Crystal Structure of the Autoinhibited Dimer of Pro-apoptotic BAX (I) | x-ray diffraction | A, B | — | — |
| 4S0O | Crystal structure of the autoinhibited dimer of pro-apoptotic bax (I) | x-ray diffraction | A, B | — | — |
| 4S0P | Crystal Structure of the Autoinhibited Dimer of Pro-apoptotic BAX (II) | x-ray diffraction | A, B | — | — |
| 4S0P | Crystal structure of the autoinhibited dimer of pro-apoptotic bax (II) | x-ray diffraction | A, B | — | — |
| 4UF2 | Deerpox virus DPV022 in complex with Bax BH3 | x-ray diffraction | B | — | — |
| 4UF2 | Deerpox virus DPV022 in complex with bax BH3 | x-ray diffraction | B | — | — |
| 4ZIE | Crystal Structure of core/latch dimer of Bax in complex with BimBH3 | x-ray diffraction | A | — | — |
| 4ZIE | Crystal structure of CORE/LATCH dimer of bax in complex with BIMBH3 | x-ray diffraction | A | — | — |
| 4ZIF | Crystal Structure of core/latch dimer of Bax in complex with BimBH3mini | x-ray diffraction | A | — | — |
| 4ZIF | Crystal structure of CORE/LATCH dimer of bax in complex with BIMBH3MINI | x-ray diffraction | A | — | — |
| 4ZIG | Crystal Structure of core/latch dimer of Bax in complex with BidBH3mini | x-ray diffraction | A | — | 2 (best 0.37) |
| 4ZIG | Crystal structure of CORE/LATCH dimer of bax in complex with BIDBH3MINI | x-ray diffraction | A | — | — |
| 4ZIH | Crystal Structure of core/latch dimer of Bax in complex with BimBH3mini | x-ray diffraction | A | — | 1 (best 0.36) |
| 4ZIH | Crystal structure of CORE/LATCH dimer of bax in complex with BIMBH3MINI | x-ray diffraction | A | — | — |
| 4ZII | Crystal Structure of core/latch dimer of BaxI66A in complex with BidBH3 | x-ray diffraction | A | — | — |
| 4ZII | Crystal structure of CORE/LATCH dimer of BAXI66A in complex with BIDBH3 | x-ray diffraction | A | — | — |
| 5W5X | Crystal structure of BAXP168G in complex with an activating antibody | x-ray diffraction | A | — | 2 (best 0.61) |
| 5W5X | Crystal structure of BAXP168G in complex with an activating antibody | x-ray diffraction | A | — | — |
| 5W5Z | Crystal structure of BAXP168G in complex with an activating antibody at high resolution | x-ray diffraction | A | — | 2 (best 0.53) |
| 5W5Z | Crystal structure of BAXP168G in complex with an activating antibody at high resolution | x-ray diffraction | A | — | — |
| 5W60 | Crystal structure of BAXP168G monomer cryo-protected with ethylene glycol | x-ray diffraction | A | SO4 | 1 (best 0.35) |
| 5W60 | Crystal structure of BAXP168G monomer cryo-protected with ethylene glycol | x-ray diffraction | A | SO4 | — |
| 5W61 | Crystal structure of BAXP168G monomer co-crystallized with glycerol | x-ray diffraction | A | — | — |
| 5W61 | Crystal structure of BAXP168G monomer co-crystallized with glycerol | x-ray diffraction | A | — | — |
| 6EB6 | Crystal structure of BAX W139A monomer | x-ray diffraction | A | — | 1 (best 0.48) |
| 6EB6 | Crystal structure of bax W139A monomer | x-ray diffraction | A | — | — |
| 6L8V | Membrane-bound bax HELIX2-HELIX5 domain | solution nmr | A, B | — | — |
| 6L95 | transmembrane-domain of Bax | solution nmr | A, B | — | — |
| 6L95 | Transmembrane-domain of bax | solution nmr | A, B | — | — |
| 6TRR | Structural insight into tanapoxvirus mediated inhibition of apoptosis | x-ray diffraction | B | — | — |
| 6TRR | Structural insight into tanapoxvirus mediated inhibition of apoptosis | x-ray diffraction | B | — | — |
| 6XY6 | Structural insight into sheep-pox virus mediated inhibition of apoptosis | x-ray diffraction | B, D, F, H, J, L, N, P | — | — |
| 6XY6 | Structural insight into sheep-pox virus mediated inhibition of apoptosis | x-ray diffraction | B, D, F, H, J, L, N, P | — | — |
| 7ADT | Orf virus Apoptosis inhibitor ORFV125 | x-ray diffraction | U, C | MG | 2 (best 0.40) |
| 7ADT | Orf virus apoptosis inhibitor ORFV125 | x-ray diffraction | U, C | MG | — |
| 8G1T | Crystal structure of Bax core domain BH3-groove dimer - tetrameric fraction P21 | x-ray diffraction | A, B, C, D, E, F, G, H | — | 4 (best 0.66) |
| 8SPE | Crystal structure of Bax core domain BH3-groove dimer - tetrameric fraction P31 | x-ray diffraction | A, B, C, D, Q, R, S, T, G, H, U, V, E, F, I, J, K, L, M, N, O, P, W, X, Y, Z, a, b, c, d, e, f, g, h, i, j | ZN | 20 (best 0.78) |
| 8SPF | Crystal structure of Bax core domain BH3-groove dimer - hexameric fraction with 2-stearoyl lysoPC | x-ray diffraction | C, D, A, B, E, F | 1GP, D12 | 6 (best 0.65) |
| 8SPZ | Crystal structure of Bax core domain BH3-groove dimer - hexameric fraction with dioctanoyl… | x-ray diffraction | A, B, C, D | SO4 | 3 (best 0.53) |
| 8SRX | Crystal structure of BAK-BAX heterodimer with lysoPC | x-ray diffraction | B, D | K6G, NA, CL | 1 (best 0.86) |
3 records more on the page itself.
Ligands
- SO4 · Sulfate ion · in 4 records
- MG · Magnesium ion · in 2 records
- 1GP · Sn-glycerol-1-phosphate · in 1 record
- CL · Chloride ion · in 1 record
- D12 · Dodecane · in 1 record
- K6G · [(2~{R})-2-oxidanyl-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-propyl] hexadecanoate · in 1 record
- N8E · 3,6,9,12,15-pentaoxatricosan-1-ol · in 1 record
- NA · Sodium ion · in 1 record
- ZN · Zinc ion · in 1 record
Experiment against prediction
- 6EB6 chain A against the predicted model Q07812: TM-score 0.97, RMSD 1.02 Å
- 6EB6 chain A against the predicted model Q07812: TM-score 0.97, RMSD 1.02 Å
- 5W61 chain A against the predicted model Q07812: TM-score 0.96, RMSD 1.08 Å
- 5W61 chain A against the predicted model Q07812: TM-score 0.96, RMSD 1.08 Å
- 4S0O chain A against the predicted model Q07812: TM-score 0.95, RMSD 1.28 Å
- 4S0O chain A against the predicted model Q07812: TM-score 0.95, RMSD 1.28 Å
- 4S0O chain B against the predicted model Q07812: TM-score 0.95, RMSD 1.28 Å
- 4S0O chain B against the predicted model Q07812: TM-score 0.95, RMSD 1.28 Å
- 4S0P chain B against the predicted model Q07812: TM-score 0.95, RMSD 1.31 Å
- 4S0P chain B against the predicted model Q07812: TM-score 0.95, RMSD 1.31 Å
Elsewhere
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