MolNFT v1 · #42088 · protein
Bax activation is initiated at a novel interaction site
2K7W · Apoptosis regulator bax: “Bax activation is initiated at a novel interaction site”. Solution nmr, 4 pockets (best druggability 0.70). MolNFT v1 #42088 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2K7W
- Type
- protein
- Length
- 212 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Apoptosis regulator bax; BCL-2-like protein 11
- UniProt
- Q07812, O43521
- Pockets
- 4 · best druggability 0.70
Structure
solution nmr · 2 distinct chains · 68% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Apoptosis regulator bax | protein | 192 | 66% helix, 0% strand | Q07812 |
| B | BCL-2-like protein 11 | protein | 20 | 85% helix, 0% strand | O43521 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 183 | 0.70 | 0.87 | 45 | empty |
| 2 | 248 | 0.67 | 0.83 | 28 | empty |
| 3 | 115 | 0.43 | 0.77 | 17 | empty |
| 4 | 87 | 0.37 | 0.75 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 928 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
- 2K7W · BAX Activation is Initiated at a Novel Interaction Site · the same entry in another collection · chain A against A, TM-score 1.00
- Q07812 · AlphaFold monomer V2.0 prediction for apoptosis regulator bax (Q07812) · a predicted model of the same protein · chain A against A, TM-score 0.81
- O43521 · AlphaFold monomer V2.0 prediction for BCL-2-like protein 11 (O43521) · a predicted model of the same protein · chain B against A, TM-score 0.62
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q07812
- Every structure of UniProt O43521
- Elsewhere: RCSB PDB 2K7W · PDBe 2K7W · UniProt Q07812 · UniProt O43521
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.