UniProt O43521
Bcl-2-like protein 11 (O43521)
Bcl-2-like protein 11 (UniProt O43521): 71 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 11 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O43521
- Protein
- Bcl-2-like protein 11
- Experimental structures
- 71
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 11 · 3 records with a druggable one
Structures
72 records of O43521 in the MolNFT archive: 71 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1F95 | Solution structure of dynein light chain 8 (DLC8) and bim peptide complex | solution nmr | C, D | — | — |
| 1F95 | Solution structure of dynein light chain 8 (DLC8) and bim peptide complex | solution nmr | C, D | — | — |
| 2K7W | BAX Activation is Initiated at a Novel Interaction Site | solution nmr | B | — | — |
| 2K7W | Bax activation is initiated at a novel interaction site | solution nmr | B | — | — |
| 2NL9 | Crystal structure of the Mcl-1:Bim BH3 complex | x-ray diffraction | B | — | — |
| 2NL9 | Crystal structure of the mcl-1:BIM BH3 complex | x-ray diffraction | B | — | — |
| 2V6Q | Crystal Structure of a BHRF-1 : Bim BH3 complex | x-ray diffraction | B | — | — |
| 2V6Q | Crystal structure of a bhrf-1 : bim BH3 complex | x-ray diffraction | B | — | — |
| 2VM6 | Human Bcl2-A1 in complex with Bim-BH3 peptide | x-ray diffraction | B | — | — |
| 2VM6 | Human BCL2-A1 in complex with bim-BH3 peptide | x-ray diffraction | B | — | — |
| 2WH6 | Crystal structure of anti-apoptotic BHRF1 in complex with the Bim BH3 domain | x-ray diffraction | B | — | — |
| 2WH6 | Crystal structure of anti-apoptotic BHRF1 in complex with the bim BH3 domain | x-ray diffraction | B | — | — |
| 2YQ6 | Structure of Bcl-xL bound to BimSAHB | x-ray diffraction | B | — | — |
| 2YQ6 | Structure of BCL-xl bound to bimsahb | x-ray diffraction | B | — | — |
| 2YQ7 | Structure of Bcl-xL bound to BimLOCK | x-ray diffraction | B | — | — |
| 2YQ7 | Structure of BCL-xl bound to bimlock | x-ray diffraction | B | — | — |
| 3D7V | Crystal structure of Mcl-1 in complex with an Mcl-1 selective BH3 ligand | x-ray diffraction | B | — | — |
| 3D7V | Crystal structure of mcl-1 in complex with an mcl-1 selective BH3 ligand | x-ray diffraction | B | — | — |
| 3FDL | Bim BH3 peptide in complex with Bcl-xL | x-ray diffraction | B | — | — |
| 3FDL | Bim BH3 peptide in complex with BCL-xl | x-ray diffraction | B | — | — |
| 3IO8 | BimL12F in complex with Bcl-xL | x-ray diffraction | B, D | — | — |
| 3IO8 | BIML12F in complex with BCL-xl | x-ray diffraction | B, D | — | — |
| 3IO9 | BimL12Y in complex with Mcl-1 | x-ray diffraction | B | — | — |
| 3IO9 | BIML12Y in complex with mcl-1 | x-ray diffraction | B | — | — |
| 3KJ0 | Mcl-1 in complex with Bim BH3 mutant I2dY | x-ray diffraction | B | — | — |
| 3KJ0 | Mcl-1 in complex with bim BH3 mutant I2DY | x-ray diffraction | B | — | — |
| 3KJ1 | Mcl-1 in complex with Bim BH3 mutant I2dA | x-ray diffraction | B | — | — |
| 3KJ1 | Mcl-1 in complex with bim BH3 mutant I2DA | x-ray diffraction | B | — | — |
| 3KJ2 | Mcl-1 in complex with Bim BH3 mutant F4aE | x-ray diffraction | B | — | — |
| 3KJ2 | Mcl-1 in complex with bim BH3 mutant F4AE | x-ray diffraction | B | — | — |
| 4B4S | Crystal Structure of a pro-survival Bcl-2:Bim BH3 complex | x-ray diffraction | B | — | — |
| 4B4S | Crystal structure of a pro-survival BCL-2:BIM BH3 complex | x-ray diffraction | B | — | — |
| 4D2M | Vaccinia Virus F1L bound to Bim BH3 | x-ray diffraction | B, D | — | — |
| 4D2M | Vaccinia virus F1L bound to bim BH3 | x-ray diffraction | B, D | — | — |
| 4QVF | Crystal structure of Bcl-xL in complex with BIM BH3 domain | x-ray diffraction | B | — | — |
| 4QVF | Crystal structure of BCL-xl in complex with bim BH3 domain | x-ray diffraction | B | — | — |
| 4UF3 | Deerpox virus DPV022 in complex with Bim BH3 | x-ray diffraction | B | — | — |
| 4UF3 | Deerpox virus DPV022 in complex with bim BH3 | x-ray diffraction | B | — | — |
| 4ZIE | Crystal Structure of core/latch dimer of Bax in complex with BimBH3 | x-ray diffraction | C | — | — |
| 4ZIE | Crystal structure of CORE/LATCH dimer of bax in complex with BIMBH3 | x-ray diffraction | C | — | — |
| 4ZIF | Crystal Structure of core/latch dimer of Bax in complex with BimBH3mini | x-ray diffraction | B | — | — |
| 4ZIF | Crystal structure of CORE/LATCH dimer of bax in complex with BIMBH3MINI | x-ray diffraction | B | — | — |
| 4ZIH | Crystal Structure of core/latch dimer of Bax in complex with BimBH3mini | x-ray diffraction | B | — | — |
| 4ZIH | Crystal structure of CORE/LATCH dimer of bax in complex with BIMBH3MINI | x-ray diffraction | B | — | — |
| 5AGW | Bcl-2 alpha beta-1 complex | x-ray diffraction | C, D | — | — |
| 5AGW | BCL-2 alpha beta-1 complex | x-ray diffraction | C, D | — | — |
| 5AGX | Bcl-2 alpha beta-1 LINEAR complex | x-ray diffraction | C, D | — | 4 (best 0.59) |
| 5AGX | BCL-2 alpha beta-1 linear complex | x-ray diffraction | C, D | — | — |
| 5C3G | Crystal structure of BCL-xl bound to bim-mm | x-ray diffraction | B | — | — |
| 5VWV | Bak core latch dimer in complex with bim-BH3 - cubic | x-ray diffraction | B | CL | — |
| 5VWW | Bak core latch dimer in complex with Bim-RT - Tetragonal | x-ray diffraction | C, D | BR | 2 (best 0.77) |
| 5VWW | Bak core latch dimer in complex with bim-rt - tetragonal | x-ray diffraction | C, D | BR | — |
| 5VWX | Bak core latch dimer in complex with Bim-h0-h3Glt | x-ray diffraction | B, D | — | — |
| 5VWX | Bak core latch dimer in complex with bim-H0-H3GLT | x-ray diffraction | B, D | — | — |
| 5VWY | Bak core latch dimer in complex with Bim-h3Pc-RT | x-ray diffraction | B | PO4 | — |
| 5VWY | Bak core latch dimer in complex with bim-H3PC-rt | x-ray diffraction | B | PO4 | — |
| 5VWZ | Bak in complex with Bim-h3Pc | x-ray diffraction | B, D | 1PG, NH4 | — |
| 5VWZ | Bak in complex with bim-H3PC | x-ray diffraction | B, D | 1PG, NH4 | — |
| 5VX0 | Bak in complex with bim-H3GLG | x-ray diffraction | B, D | MG | — |
| 5VX2 | Mcl-1 in complex with bim-H3PC-rt | x-ray diffraction | B, D | — | — |
12 records more on the page itself.
Ligands
- 1PG · 2-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethanol · in 2 records
- BR · Bromide ion · in 2 records
- NH4 · Ammonium ion · in 2 records
- PO4 · Phosphate ion · in 2 records
- SCN · Thiocyanate ion · in 2 records
- CL · Chloride ion · in 1 record
- MG · Magnesium ion · in 1 record
- NH2 · Amino group · in 1 record
- ZN · Zinc ion · in 1 record
Experiment against prediction
- 5VWZ chain D against the predicted model O43521: TM-score 0.81, RMSD 0.71 Å
- 5VWZ chain D against the predicted model O43521: TM-score 0.81, RMSD 0.71 Å
- 5VWY chain B against the predicted model O43521: TM-score 0.81, RMSD 0.88 Å
- 5VWY chain B against the predicted model O43521: TM-score 0.81, RMSD 0.88 Å
- 3KJ2 chain B against the predicted model O43521: TM-score 0.80, RMSD 0.32 Å
- 3KJ2 chain B against the predicted model O43521: TM-score 0.80, RMSD 0.32 Å
- 4ZIF chain B against the predicted model O43521: TM-score 0.80, RMSD 0.28 Å
- 4ZIF chain B against the predicted model O43521: TM-score 0.80, RMSD 0.28 Å
- 5VWV chain B against the predicted model O43521: TM-score 0.80, RMSD 0.87 Å
- 3D7V chain B against the predicted model O43521: TM-score 0.80, RMSD 0.40 Å
Elsewhere
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