MolNFT v1 · #112344 · protein
Crystal structure of CORE/LATCH dimer of bax in complex with BIMBH3MINI
4ZIF · Apoptosis regulator bax: “Crystal structure of CORE/LATCH dimer of bax in complex with BIMBH3MINI”. X-ray diffraction, 1 pocket (best druggability 0.32). MolNFT v1 #112344 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 4ZIF
- Type
- protein
- Length
- 162 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Apoptosis regulator bax; BCL-2-like protein 11
- UniProt
- Q07812, O43521
- Pockets
- 1 · best druggability 0.32
Structure
x-ray diffraction · 2 distinct chains · 78% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Apoptosis regulator bax | protein | 146 | 77% helix, 0% strand | Q07812 |
| B | BCL-2-like protein 11 | protein | 16 | 88% helix, 0% strand | O43521 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 62 | 0.32 | 0.75 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 741 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 4ZIF · Crystal Structure of core/latch dimer of Bax in complex with BimBH3mini · the same entry in another collection · chain A against A, TM-score 1.00
- O43521 · AlphaFold monomer V2.0 prediction for BCL-2-like protein 11 (O43521) · a predicted model of the same protein · chain B against A, TM-score 0.80
- Q07812 · AlphaFold monomer V2.0 prediction for apoptosis regulator bax (Q07812) · a predicted model of the same protein · chain A against A, TM-score 0.69
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q07812
- Every structure of UniProt O43521
- Elsewhere: RCSB PDB 4ZIF · PDBe 4ZIF · UniProt Q07812 · UniProt O43521
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