UniProt Q06278
Aldehyde oxidase (Q06278)
Aldehyde oxidase (UniProt Q06278), EC 1.17.3.-, 1.2.3.1: 11 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 40 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q06278
- Protein
- Aldehyde oxidase
- EC
- 1.17.3.-, 1.2.3.1
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 40 · 2 records with a druggable one
Structures
12 records of Q06278 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4UHW | Human aldehyde oxidase | x-ray diffraction | A | — | — |
| 4UHW | Human aldehyde oxidase | x-ray diffraction | A | — | — |
| 4UHX | Human aldehyde oxidase in complex with phthalazine and thioridazine | x-ray diffraction | A | — | — |
| 4UHX | Human aldehyde oxidase in complex with phthalazine and thioridazine | x-ray diffraction | A | — | — |
| 5EPG | Human aldehyde oxidase SNP S1271L | x-ray diffraction | A | FES, MTE, FAD, MOS | — |
| 5EPG | Human aldehyde oxidase SNP S1271L | x-ray diffraction | A | — | — |
| 6Q6Q | Human aldehyde oxidase SNP G1269R | x-ray diffraction | A | FES, FAD | — |
| 7OPN | Human Aldehyde Oxidase SNP R1231H in complex with Raloxifene | x-ray diffraction | A, B | FES, MTE, MOS, FAD, RAL | 20 (best 0.85) |
| 7OPN | Human aldehyde oxidase SNP R1231H in complex with raloxifene | x-ray diffraction | A, B | FES, MTE, MOS, FAD, RAL | — |
| 7ORC | Human aldehyde oxidase in complex with raloxifene | x-ray diffraction | A, B | FES, MTE, MOS, FAD, RAL | — |
| 8EMT | Cryo-EM analysis of the human aldehyde oxidase from liver | electron microscopy | B, A | FES, MTE, MOS, FAD | 20 (best 0.84) |
| Q06278 | AlphaFold monomer V2.0 prediction for aldehyde oxidase (Q06278) | predicted | A | — | — |
Ligands
- FAD · Flavin-adenine dinucleotide · in 6 records
- FES · Fe2/s2 (inorganic) cluster · in 6 records
- MOS · Dioxothiomolybdenum(vi) ion · in 5 records
- MTE · Phosphonic acidmono-(2-amino-5,6-dimercapto-4-oxo-3,7,8A,9,10,10A-hexahydro-4H-8-oxa-1,3,9,10-tetraaza-anthracen-7-ylmethyl)ester · in 5 records
- RAL · Raloxifene · in 3 records
Experiment against prediction
- 6Q6Q chain A against the predicted model Q06278: TM-score 1.00, RMSD 0.71 Å
- 5EPG chain A against the predicted model Q06278: TM-score 1.00, RMSD 0.72 Å
- 5EPG chain A against the predicted model Q06278: TM-score 1.00, RMSD 0.72 Å
- 4UHX chain A against the predicted model Q06278: TM-score 1.00, RMSD 0.73 Å
- 4UHX chain A against the predicted model Q06278: TM-score 1.00, RMSD 0.73 Å
- 4UHW chain A against the predicted model Q06278: TM-score 1.00, RMSD 0.74 Å
- 4UHW chain A against the predicted model Q06278: TM-score 1.00, RMSD 0.74 Å
- 7ORC chain B against the predicted model Q06278: TM-score 1.00, RMSD 0.81 Å
- 7ORC chain A against the predicted model Q06278: TM-score 1.00, RMSD 0.81 Å
- 7OPN chain B against the predicted model Q06278: TM-score 1.00, RMSD 0.83 Å
Elsewhere
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