UniProt Q05940
Synaptic vesicular amine transporter (Q05940)
Synaptic vesicular amine transporter (UniProt Q05940): 18 experimental structures on GenesisL1, 9 ligands bound, 73 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q05940
- Protein
- Synaptic vesicular amine transporter
- Experimental structures
- 18
- Predicted models
- 0
- Ligands
- 9
- Pockets
- 73 · 17 records with a druggable one
Structures
18 records of Q05940 in the MolNFT archive: 18 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8JSW | Human VMAT2 complex with serotonin | electron microscopy | A | SRO | 2 (best 0.79) |
| 8JT5 | VMAT2 complex with histamine | electron microscopy | A | HSM | 2 (best 0.79) |
| 8JTC | Human VMAT2 complex with reserpine | electron microscopy | A | YHR | 4 (best 0.79) |
| 8T69 | Human VMAT2 in complex with tetrabenazine | electron microscopy | A | YHL | 3 (best 0.86) |
| 8THR | Structure of the human vesicular monoamine transporter 2 (VMAT2) bound to tetrabenazine in an… | electron microscopy | A | EBZ | 1 (best 0.83) |
| 8UCK | Komagataella pastoris Cytochrome c oxidase (9 subunits) in complex with human VMAT2 | electron microscopy | A | — | 3 (best 0.76) |
| 8UCL | Komagataella pastoris Cytochrome c oxidase in complex with human VMAT2 and Tetrabenazine | electron microscopy | A | EBZ | 4 (best 0.86) |
| 8UCM | Komagataella pastoris Cytochrome c oxidase in complex with human VMAT2 and Reserpine | electron microscopy | A | YHR | 4 (best 0.79) |
| 8UCN | Komagataella pastoris Cytochrome c oxidase in complex with human VMAT2 and Histamine | electron microscopy | A | HSM | 6 (best 0.82) |
| 8UCO | CryoEM structure of Komagataella pastoris Cytochrome c oxidase (9 subunits) in complex with human… | electron microscopy | A | 1WE | 5 (best 0.81) |
| 8UCP | Komagataella pastoris Cytochrome c oxidase in complex with human VMAT2 and Serotonin | electron microscopy | A | SRO | 9 (best 0.82) |
| 8WLJ | Cryo-EM structure of human apo VMAT2 with nanobody in an outward-facing conformation | electron microscopy | A | — | 6 (best 0.75) |
| 8WLK | Cryo-EM structure of human VMAT2 in presence of Tetrabenazine, determined in an outward-facing… | electron microscopy | A | EBZ | 5 (best 0.87) |
| 8WRD | Transporter apo state | electron microscopy | A | — | 6 (best 0.78) |
| 8WVG | Transporter bound with inhibitor | electron microscopy | A | XEQ | 6 (best 0.85) |
| 8XO9 | VMAT2 complex with noradrenaline in cytosol-facing state | electron microscopy | A | E5E | 4 (best 0.81) |
| 8XOA | VMAT2 complex with MPP+ | electron microscopy | A | WRF | 3 (best 0.79) |
| Q05940 | AlphaFold monomer V2.0 prediction for synaptic vesicular amine transporter (Q05940) | — | — | — |
Ligands
- EBZ · (3S,5R,11bS)-9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one · in 3 records
- HSM · Histamine · in 2 records
- SRO · Serotonin · in 2 records
- YHR · reserpine · in 2 records
- 1WE · (2S)-1-phenylpropan-2-amine · in 1 record
- E5E · Noradrenaline · in 1 record
- WRF · 1-methyl-4-phenylpyridin-1-ium · in 1 record
- XEQ · (3~{S},11~{b}~{R})-9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11~{b}-hexahydrobenzo[a]quinolizin-2-one · in 1 record
- YHL · tetrabenazine · in 1 record
Elsewhere
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