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Ligand · YHR

YHR · reserpine

YHR, reserpine (C33 H40 N2 O9, 608.7 g/mol), in the MolNFT structures on GenesisL1: bound in 12 records (12 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
YHR
Formula
C33 H40 N2 O9
Class
ligand
Structures
12
PDB entries
12

Binding sites

YHR in 12 structures; the first of them:

  • 8JTC · Human VMAT2 complex with reserpine · YHR A501 · binds ASN34, LEU37, THR38, VAL41, LEU225, LEU228, ALA229, VAL232 and 16 more
  • 8T6A · Human VMAT2 in complex with reserpine · YHR A601 · binds ASN34, LEU37, THR38, VAL41, LEU225, LEU228, ALA229, VAL232 and 14 more
  • 8TGG · VMAT1 dimer with MPP+ and reserpine · YHR B601 · binds ASN35, PHE38, THR39, VAL42, LEU233, LEU236, LEU240, ALA244 and 16 more
  • 8TGH · VMAT1 dimer with amphetamine and reserpine · YHR B601 · binds ASN35, PHE38, THR39, VAL42, LEU233, LEU236, LEU240, ALA244 and 15 more
  • 8TGI · VMAT1 dimer with dopamine and reserpine · YHR B601 · binds ASN35, PHE38, THR39, VAL42, LEU233, LEU236, LEU240, ASN313 and 15 more
  • 8TGJ · VMAT1 dimer in unbound form and with reserpine · YHR B601 · binds ASN35, PHE38, THR39, VAL42, LEU233, LEU236, LEU240, ALA244 and 15 more
  • 8TGK · VMAT1 dimer with histamine and reserpine · YHR B601 · binds ASN35, PHE38, THR39, VAL42, LEU233, LEU236, LEU240, ALA244 and 15 more
  • 8TGL · VMAT1 dimer with norepinephrine and reserpine · YHR B601 · binds ASN35, PHE38, THR39, VAL42, LEU233, LEU236, LEU240, ALA244 and 16 more
  • 8TGM · VMAT1 dimer with reserpine · YHR A601 · binds ASN35, PHE38, THR39, VAL42, LEU233, LEU236, LEU240, ALA244 and 16 more
  • 8TGN · VMAT1 dimer with serotonin and reserpine · YHR B601 · binds ASN35, PHE38, THR39, VAL42, LEU233, LEU236, LEU240, ALA244 and 16 more
  • 8UCM · Komagataella pastoris Cytochrome c oxidase in complex with human VMAT2 and Reserpine · YHR A601 · binds ASN34, LEU37, THR38, VAL41, LEU225, LEU228, ALA229, VAL232 and 15 more
  • 8WLL · Cryo-EM structure of human VMAT2 Y422C, in the presence of reserpine, determined in an… · YHR A501 · binds ASN34, LEU37, THR38, VAL41, LEU225, LEU228, ALA229, VAL232 and 15 more

Residues it binds most

PHE 13, LEU 13, VAL 13, ALA 13, TYR 13, ASN 13, ASP 13, ILE 13, GLU 13, MET 13 (residue and the binding sites it lines).

Found with

  • 1WE · (2S)-1-phenylpropan-2-amine
  • CUA · Dinuclear copper ion
  • HEA · Heme-A
  • HSM · Histamine
  • LDP · L-dopamine
  • LNR · L-norepinephrine
  • PTY · Phosphatidylethanolamine
  • SRO · Serotonin
  • WRF · 1-methyl-4-phenylpyridin-1-ium
  • CU · Copper (II) ion
  • ZN · Zinc ion

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