UniProt Q05752
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (Q05752)
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (UniProt Q05752): 46 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 20 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q05752
- Protein
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
- Experimental structures
- 46
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 20 · 20 records with a druggable one
Structures
47 records of Q05752 in the MolNFT archive: 46 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5O31 | Mitochondrial complex I in the deactive state | electron microscopy | r | — | 1 (best 0.83) |
| 5O31 | Mitochondrial complex I in the deactive state | electron microscopy | r | — | — |
| 7DGQ | Activity optimized supercomplex state1 | electron microscopy | P | CDL | — |
| 7DGZ | Activity optimized complex I (closed form) | electron microscopy | P | CDL | — |
| 7DGZ | Activity optimized complex I (closed form) | electron microscopy | P | CDL | — |
| 7DH0 | Activity optimized complex I (open form) | electron microscopy | P | — | — |
| 7DH0 | Activity optimized complex I (open form) | electron microscopy | P | — | — |
| 7DKF | Activity optimized supercomplex state4 | electron microscopy | P2 | — | — |
| 7QSD | Bovine complex I in the active state at 3.1 A | electron microscopy | r | CDL | 1 (best 0.89) |
| 7QSD | Bovine complex I in the active state at 3.1 a | electron microscopy | r | CDL | — |
| 7QSK | Bovine complex I in lipid nanodisc, Active-Q10 | electron microscopy | r | PC1, CDL | 1 (best 0.90) |
| 7QSK | Bovine complex I in lipid nanodisc, active-Q10 | electron microscopy | r | PC1, CDL | — |
| 7QSL | Bovine complex I in lipid nanodisc, active-apo | electron microscopy | r | 3PE, CDL | — |
| 7QSM | Bovine complex I in lipid nanodisc, Deactive-ligand (composite) | electron microscopy | r | 3PE, CDL | — |
| 7QSM | Bovine complex I in lipid nanodisc, deactive-ligand (composite) | electron microscopy | r | 3PE, CDL | — |
| 7QSN | Bovine complex I in lipid nanodisc, Deactive-apo | electron microscopy | r | 3PE, CDL | 1 (best 0.90) |
| 7QSN | Bovine complex I in lipid nanodisc, deactive-apo | electron microscopy | r | 3PE, CDL | — |
| 7QSO | Bovine complex I in lipid nanodisc, State 3 (Slack) | electron microscopy | r | 3PE, CDL | — |
| 7QSO | Bovine complex I in lipid nanodisc, state 3 (slack) | electron microscopy | r | 3PE, CDL | — |
| 7R41 | Bovine complex I in the presence of IM1761092, active class i (Composite map) | electron microscopy | r | CDL | 1 (best 0.90) |
| 7R42 | Bovine complex I in the presence of IM1761092, active class ii (Composite map) | electron microscopy | r | CDL | — |
| 7R43 | Bovine complex I in the presence of IM1761092, active class iii (Composite map) | electron microscopy | r | CDL | — |
| 7R44 | Bovine complex I in the presence of IM1761092, active class iv (Composite map) | electron microscopy | r | CDL | — |
| 7R45 | Bovine complex I in the presence of IM1761092, deactive class i (Composite map) | electron microscopy | r | CDL | — |
| 7R46 | Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) | electron microscopy | r | 3PE, CDL | 1 (best 0.79) |
| 7R47 | Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) | electron microscopy | r | CDL | — |
| 7R48 | Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) | electron microscopy | r | CDL | 1 (best 0.80) |
| 7R4C | Bovine complex I in the presence of IM1761092, deactive class v (Composite map) | electron microscopy | r | CDL | — |
| 7R4D | Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) | electron microscopy | r | CDL | 1 (best 0.79) |
| 7R4F | Bovine complex I in the presence of IM1761092, slack class i (Composite map) | electron microscopy | r | 3PE, CDL | 1 (best 0.79) |
| 7R4G | Bovine complex I in the presence of IM1761092, slack class ii (Composite map) | electron microscopy | r | 3PE, CDL | 1 (best 0.81) |
| 8Q0A | Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. | electron microscopy | r | 3PE, PC1, CDL | — |
| 8Q0F | Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. | electron microscopy | r | PC1, 3PE, CDL | — |
| 8Q0J | Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. | electron microscopy | r | 3PE, CDL | — |
| 8Q0M | Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. | electron microscopy | r | PC1, 3PE, CDL | 1 (best 0.87) |
| 8Q0O | Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. | electron microscopy | r | 3PE, PC1, CDL | 1 (best 0.89) |
| 8Q0Q | Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM | electron microscopy | r | 3PE, CDL | 1 (best 0.81) |
| 8Q1P | Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially… | electron microscopy | r | 3PE, PC1, CDL | — |
| 8Q1U | Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially… | electron microscopy | r | 3PE, CDL | 1 (best 0.88) |
| 8Q1Y | Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially… | electron microscopy | r | 3PE, PC1, CDL | 1 (best 0.86) |
| 8Q25 | Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially… | electron microscopy | r | PC1, CDL, 3PE | — |
| 8Q46 | Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. | electron microscopy | r | PC1, 3PE, CDL | 1 (best 0.90) |
| 8Q47 | Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. | electron microscopy | r | PC1, 3PE, CDL | 1 (best 0.79) |
| 8Q48 | Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. | electron microscopy | r | PC1, 3PE, CDL | 1 (best 0.87) |
| 8Q49 | Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. | electron microscopy | r | PC1, 3PE, CDL | 1 (best 0.90) |
| 8Q4A | Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. | electron microscopy | r | PC1, CDL, 3PE | 1 (best 0.88) |
| Q05752 | AlphaFold monomer V2.0 prediction for NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7… | predicted | A | — | — |
Ligands
Experiment against prediction
- 7R4C chain r against the predicted model Q05752: TM-score 0.95, RMSD 0.84 Å
- 7R41 chain r against the predicted model Q05752: TM-score 0.95, RMSD 0.85 Å
- 8Q46 chain r against the predicted model Q05752: TM-score 0.95, RMSD 0.85 Å
- 7R4F chain r against the predicted model Q05752: TM-score 0.95, RMSD 0.85 Å
- 7R4D chain r against the predicted model Q05752: TM-score 0.95, RMSD 0.85 Å
- 7R42 chain r against the predicted model Q05752: TM-score 0.95, RMSD 0.85 Å
- 7R44 chain r against the predicted model Q05752: TM-score 0.95, RMSD 0.85 Å
- 7R45 chain r against the predicted model Q05752: TM-score 0.95, RMSD 0.85 Å
- 8Q49 chain r against the predicted model Q05752: TM-score 0.95, RMSD 0.86 Å
- 7R43 chain r against the predicted model Q05752: TM-score 0.95, RMSD 0.86 Å
Elsewhere
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