UniProt Q05193
Dynamin-1 (Q05193)
Dynamin-1 (UniProt Q05193), EC 3.6.5.5: 32 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 128 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q05193
- Protein
- Dynamin-1
- EC
- 3.6.5.5
- Experimental structures
- 32
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 128 · 9 records with a druggable one
Structures
33 records of Q05193 in the MolNFT archive: 32 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1DYN | Crystal structure at 2.2 ångströms resolution of the pleckstrin homology domain from human dynamin | x-ray diffraction | A, B | — | — |
| 1DYN | Crystal structure at 2.2 ångströms resolution of the pleckstrin homology domain from human dynamin | x-ray diffraction | A, B | — | — |
| 2DYN | Dynamin (pleckstrin homology domain) (dynph) | x-ray diffraction | A, B | — | — |
| 2DYN | Dynamin (pleckstrin homology domain) (dynph) | x-ray diffraction | A, B | — | — |
| 2X2E | Dynamin GTPase dimer, long axis form | x-ray diffraction | A, D | — | — |
| 2X2E | Dynamin GTPase dimer, long axis form | x-ray diffraction | A, D | — | — |
| 2X2F | Dynamin 1 GTPase dimer, short axis form | x-ray diffraction | A, D | — | — |
| 2X2F | Dynamin 1 GTPase dimer, short axis form | x-ray diffraction | A, D | — | — |
| 3SNH | Crystal structure of nucleotide-free human dynamin1 | x-ray diffraction | A | — | — |
| 3SNH | Crystal structure of nucleotide-free human DYNAMIN1 | x-ray diffraction | A | — | — |
| 3ZYC | Dynamin 1 GTPase ged fusion dimer complexed with gmppcp | x-ray diffraction | A, D | — | — |
| 3ZYC | Dynamin 1 GTPase ged fusion dimer complexed with gmppcp | x-ray diffraction | A, D | — | — |
| 3ZYS | Human dynamin 1 deltaPRD polymer stabilized with GMPPCP | electron microscopy | A, C, D, F | — | — |
| 3ZYS | Human dynamin 1 deltaprd polymer stabilized with gmppcp | electron microscopy | A, C, D, F | — | — |
| 4UUD | Human dynamin 1 K44A superconstricted polymer stabilized with GTP | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 4UUD | Human dynamin 1 K44A superconstricted polymer stabilized with GTP | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 4UUK | Human dynamin 1 K44A superconstricted polymer stabilized with GTP strand 2 | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 4UUK | Human dynamin 1 K44A superconstricted polymer stabilized with GTP strand 2 | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 5D3Q | Dynamin 1 GTPase-BSE fusion dimer complexed with GDP | x-ray diffraction | A, B | GDP | 1 (best 0.84) |
| 5D3Q | Dynamin 1 GTPase-bse fusion dimer complexed with GDP | x-ray diffraction | A, B | — | — |
| 6DLU | Cryo-EM of the gmppcp-bound human dynamin-1 polymer assembled on the membrane in the constricted… | electron microscopy | B, P | GCP, MG | — |
| 6DLV | Cryo-EM of the GTP-bound human dynamin-1 polymer assembled on the membrane in the super constricted… | electron microscopy | b, c, f, g | — | 20 (best 0.83) |
| 6DLV | Cryo-EM of the GTP-bound human dynamin-1 polymer assembled on the membrane in the super constricted… | electron microscopy | b, c, f, g | — | — |
| 6S9A | Artificial GTPase-BSE dimer of human Dynamin1 | x-ray diffraction | A, B | ZN, CL | 2 (best 0.68) |
| 6S9A | Artificial GTPase-bse dimer of human DYNAMIN1 | x-ray diffraction | A, B | ZN, CL | — |
| 7AX3 | CryoEM structure of the super-constricted two-start dynamin 1 filament | electron microscopy | C2, D2, A2, B2, A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, E2, F2, G2, H2, I2, J2 | GCP, MG | 20 (best 0.85) |
| 8SZ4 | Cryo-EM of the GDP-bound human dynamin polymer assembled on the membrane in the super constricted… | electron microscopy | f | — | 2 (best 0.40) |
| 8SZ7 | Cryo-EM of the GDP-bound human dynamin polymer assembled on the membrane in the super constricted… | electron microscopy | g | — | 3 (best 0.54) |
| 8SZ8 | Cryo-EM of the GDP-bound human dynamin polymer assembled on the membrane in the super constricted… | electron microscopy | b, c, f, g | GDP, MG | 20 (best 0.85) |
| 8T0R | Cryo-EM of the GDP-bound human dynamin (full-length) polymer assembled on the membrane in the super… | electron microscopy | b, c, f, g | GDP, MG | 20 (best 0.85) |
| 8TYM | Cryo-EM of the GDP-bound human dynamin (full-length) polymer assembled on the membrane in the super… | electron microscopy | c, f, B, C | GDP, MG | 20 (best 0.82) |
| 8TYN | Cryo-EM of the GDP-bound human dynamin polymer assembled on the membrane in the super constricted… | electron microscopy | c, f, C, F | GDP, MG | 20 (best 0.82) |
| Q05193 | AlphaFold monomer V2.0 prediction for dynamin-1 (Q05193) | predicted | A | — | — |
Ligands
Experiment against prediction
- 2DYN chain A against the predicted model Q05193: TM-score 0.96, RMSD 0.95 Å
- 2DYN chain A against the predicted model Q05193: TM-score 0.96, RMSD 0.95 Å
- 5D3Q chain B against the predicted model Q05193: TM-score 0.95, RMSD 1.94 Å
- 5D3Q chain B against the predicted model Q05193: TM-score 0.95, RMSD 1.94 Å
- 5D3Q chain A against the predicted model Q05193: TM-score 0.94, RMSD 1.93 Å
- 5D3Q chain A against the predicted model Q05193: TM-score 0.94, RMSD 1.93 Å
- 2DYN chain B against the predicted model Q05193: TM-score 0.94, RMSD 1.14 Å
- 2DYN chain B against the predicted model Q05193: TM-score 0.94, RMSD 1.14 Å
- 1DYN chain A against the predicted model Q05193: TM-score 0.94, RMSD 1.25 Å
- 1DYN chain A against the predicted model Q05193: TM-score 0.94, RMSD 1.25 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.