MolNFT v1 · #35031 · protein

Dynamin (pleckstrin homology domain) (dynph)

2DYN: “Dynamin (pleckstrin homology domain) (dynph)”. X-ray diffraction, 1 pocket (best druggability 0.39). MolNFT v1 #35031 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2DYN
Type: protein
Length: 222 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Dynamin
UniProt: Q05193
Pockets: 1 · best druggability 0.39

Structure

x-ray diffraction · 1 distinct chain · 12% helix, 45% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Dynamin	protein	111	12% helix, 45% strand	Q05193

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	68	0.39	0.79	18	empty

Interfaces

1 interface between chains.

A–B · 717 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

2DYN · Dynamin (pleckstrin homology domain) (dynph) · the same entry in another collection · chain B against B, TM-score 1.00
Q05193 · AlphaFold monomer V2.0 prediction for dynamin-1 (Q05193) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q05193
Elsewhere: RCSB PDB 2DYN · PDBe 2DYN · UniProt Q05193

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