UniProt Q03555
Gephyrin (Q03555)
Gephyrin (UniProt Q03555), EC 2.10.1.1, 2.7.7.75: 43 experimental structures and 1 predicted model on GenesisL1, 15 ligands bound, 19 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q03555
- Protein
- Gephyrin
- EC
- 2.10.1.1, 2.7.7.75
- Experimental structures
- 43
- Predicted models
- 1
- Ligands
- 15
- Pockets
- 19 · 0 records with a druggable one
Structures
44 records of Q03555 in the MolNFT archive: 43 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1IHC | X-ray Structure of Gephyrin N-terminal Domain | x-ray diffraction | A | — | — |
| 1IHC | X-ray structure of gephyrin N-terminal domain | x-ray diffraction | A | — | — |
| 1T3E | Structural basis of dynamic glycine receptor clustering | x-ray diffraction | A, B | — | — |
| 1T3E | Structural basis of dynamic glycine receptor clustering | x-ray diffraction | A, B | — | — |
| 2FTS | Crystal structure of the glycine receptor-gephyrin complex | x-ray diffraction | A | — | — |
| 2FTS | Crystal structure of the glycine receptor-gephyrin complex | x-ray diffraction | A | — | — |
| 2FU3 | Crystal structure of gephyrin E-domain | x-ray diffraction | A, B | — | — |
| 2FU3 | Crystal structure of gephyrin E-domain | x-ray diffraction | A, B | — | — |
| 4PD0 | 1.7 A resolution structure of gephyrin's E-domain | x-ray diffraction | A | — | — |
| 4PD0 | 1.7 a resolution structure of GEPHYRIN'S E-domain | x-ray diffraction | A | — | — |
| 4PD1 | Structure of gephyrin E domain with Glycine-beta receptor peptide | x-ray diffraction | A | — | — |
| 4PD1 | Structure of gephyrin E domain with glycine-beta receptor peptide | x-ray diffraction | A | — | — |
| 4TK1 | Geph E in complex with a GABA receptor alpha3 subunit derived peptide in space group P21212 | x-ray diffraction | A, B | — | — |
| 4TK1 | Geph E in complex with a GABA receptor ALPHA3 subunit derived peptide in space group P21212 | x-ray diffraction | A, B | — | — |
| 4TK2 | Geph E in complex with a GABA receptor alpha3 subunit derived peptide in space group P61 | x-ray diffraction | A, B | — | — |
| 4TK2 | Geph E in complex with a GABA receptor ALPHA3 subunit derived peptide in space group P61 | x-ray diffraction | A, B | — | — |
| 4TK3 | Geph E in complex with a GABA receptor alpha3 derived double mutant peptide in spacegroup P21212 | x-ray diffraction | A, B | — | — |
| 4TK3 | Geph E in complex with a GABA receptor ALPHA3 derived double mutant peptide in spacegroup P21212 | x-ray diffraction | A, B | — | — |
| 4TK4 | GephE in complex with a GABA receptor alpha3 subunit derived double mutant peptide in space group… | x-ray diffraction | A, B | — | — |
| 4TK4 | Gephe in complex with a GABA receptor ALPHA3 subunit derived double mutant peptide in space group… | x-ray diffraction | A, B | — | — |
| 4U90 | GephE in complex with PEG crosslinked GABA receptor alpha3 subunit derived dimeric peptide | x-ray diffraction | A | — | — |
| 4U90 | Gephe in complex with peg crosslinked GABA receptor ALPHA3 subunit derived dimeric peptide | x-ray diffraction | A | — | — |
| 4U91 | GephE in complex with Para-Phenyl crosslinked Glycine receptor beta subunit derived dimeric peptide | x-ray diffraction | A | — | — |
| 4U91 | Gephe in complex with para-phenyl crosslinked glycine receptor beta subunit derived dimeric peptide | x-ray diffraction | A | — | — |
| 5ERQ | Gephyrin E domain at 1.55 angstrom resolution | x-ray diffraction | A | — | — |
| 5ERQ | Gephyrin E domain at 1.55 ångström resolution | x-ray diffraction | A | — | — |
| 5ERR | GephE in complex with Mg(2+) - ADP | x-ray diffraction | A | ADP, MG, PO4 | — |
| 5ERR | Gephe in complex with MG(2+) - ADP | x-ray diffraction | A | — | — |
| 5ERS | GephE in complex with Mg(2+) - AMP | x-ray diffraction | A | AMP, MG, PO4 | — |
| 5ERS | Gephe in complex with MG(2+) - AMP | x-ray diffraction | A | — | — |
| 5ERT | GephE in complex with Mn(2+) - ADP | x-ray diffraction | A | ADP, MN, PO4 | 6 (best 0.39) |
| 5ERT | Gephe in complex with MN(2+) - ADP | x-ray diffraction | A | — | — |
| 5ERU | Ternary complex of GephE - ADP - Molybdenum cluster | x-ray diffraction | A | CA, ADP, PO4, MO, MOO, MG | 5 (best 0.41) |
| 5ERU | Ternary complex of gephe - ADP - molybdenum cluster | x-ray diffraction | A | — | — |
| 5ERV | Ternary complex of GephE - ADP - Tungsten cluster | x-ray diffraction | A | ADP, MG, W, WO4 | — |
| 5ERV | Ternary complex of gephe - ADP - tungsten cluster | x-ray diffraction | A | — | — |
| 6FGC | Crystal structure of Gephyrin E domain in complex with Artesunate | x-ray diffraction | A | CA, ADP, PO4, D95, CL | 4 (best 0.40) |
| 6FGC | Crystal structure of gephyrin E domain in complex with artesunate | x-ray diffraction | A | ADP, PO4, D95, CL | — |
| 6FGD | Crystal structure of Gephyrin E domain in complex with Artemether | x-ray diffraction | A | CA, PO4, NA, ADP, D8Z | 4 (best 0.38) |
| 6FGD | Crystal structure of gephyrin E domain in complex with artemether | x-ray diffraction | A | CA, PO4, NA, ADP, D8Z | — |
| 6HSN | Crystal structure of the ternary complex of GephE-ADP-GABA(A) receptor derived peptide | x-ray diffraction | A | ADP, MG, PO4, NA | — |
| 6HSN | Crystal structure of the ternary complex of gephe-ADP-GABA(A) receptor derived peptide | x-ray diffraction | A | ADP, MG, PO4, NA | — |
| 6HSO | Crystal structure of the ternary complex of gephe-ADP-glycine receptor derived peptide | x-ray diffraction | A | MG, ADP, PO4, 3F7 | — |
| Q03555 | AlphaFold monomer V2.0 prediction for gephyrin (Q03555) | predicted | A | — | — |
Ligands
- ADP · Adenosine-5'-diphosphate · in 11 records
- PO4 · Phosphate ion · in 11 records
- MG · Magnesium ion · in 7 records
- CA · Calcium ion · in 4 records
- NA · Sodium ion · in 4 records
- CL · Chloride ion · in 2 records
- D8Z · Artemether · in 2 records
- D95 · Artesunate · in 2 records
- 3F7 · 1,1'-benzene-1,4-diylbis(1h-pyrrole-2,5-dione) · in 1 record
- AMP · Adenosine monophosphate · in 1 record
- MN · Manganese (II) ion · in 1 record
- MO · Molybdenum atom · in 1 record
- MOO · Molybdate ion · in 1 record
- W · Tungsten ion · in 1 record
- WO4 · Tungstate(vi)ion · in 1 record
Experiment against prediction
- 6FGC chain A against the predicted model Q03555: TM-score 0.98, RMSD 1.20 Å
- 6FGC chain A against the predicted model Q03555: TM-score 0.98, RMSD 1.20 Å
- 6HSN chain A against the predicted model Q03555: TM-score 0.98, RMSD 1.22 Å
- 6HSN chain A against the predicted model Q03555: TM-score 0.98, RMSD 1.22 Å
- 6HSO chain A against the predicted model Q03555: TM-score 0.98, RMSD 1.22 Å
- 6FGD chain A against the predicted model Q03555: TM-score 0.98, RMSD 1.31 Å
- 6FGD chain A against the predicted model Q03555: TM-score 0.98, RMSD 1.31 Å
- 5ERV chain A against the predicted model Q03555: TM-score 0.98, RMSD 1.32 Å
- 5ERV chain A against the predicted model Q03555: TM-score 0.98, RMSD 1.32 Å
- 5ERU chain A against the predicted model Q03555: TM-score 0.98, RMSD 1.20 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.