UniProt Q02380
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (Q02380)
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (UniProt Q02380): 35 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 75 pockets. Binding sites, druggability and experiment…
- UniProt
- Q02380
- Protein
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
- Experimental structures
- 35
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 75 · 19 records with a druggable one
Structures
36 records of Q02380 in the MolNFT archive: 35 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5LC5 | Structure of mammalian respiratory complex I, CLASS2 | electron microscopy | h | — | — |
| 5LDW | Structure of mammalian respiratory Complex I, class1 | electron microscopy | h | — | — |
| 5LDW | Structure of mammalian respiratory complex I, CLASS1 | electron microscopy | h | — | — |
| 5LDX | Structure of mammalian respiratory complex I, CLASS3. | electron microscopy | h | — | — |
| 5O31 | Mitochondrial complex I in the deactive state | electron microscopy | h | — | 3 (best 0.84) |
| 5O31 | Mitochondrial complex I in the deactive state | electron microscopy | h | — | — |
| 7DGQ | Activity optimized supercomplex state1 | electron microscopy | b | CDL | 3 (best 0.87) |
| 7DGZ | Activity optimized complex I (closed form) | electron microscopy | b | CDL | — |
| 7DH0 | Activity optimized complex I (open form) | electron microscopy | b | CDL | — |
| 7DKF | Activity optimized supercomplex state4 | electron microscopy | b2 | CDL | 3 (best 0.90) |
| 7QSD | Bovine complex I in the active state at 3.1 A | electron microscopy | h | CDL, 3PE, PC1 | 5 (best 0.87) |
| 7QSD | Bovine complex I in the active state at 3.1 a | electron microscopy | h | CDL, PC1 | — |
| 7QSK | Bovine complex I in lipid nanodisc, active-Q10 | electron microscopy | h | CDL, PC1 | — |
| 7QSL | Bovine complex I in lipid nanodisc, active-apo | electron microscopy | h | CDL, PC1 | — |
| 7QSM | Bovine complex I in lipid nanodisc, Deactive-ligand (composite) | electron microscopy | h | CDL, 3PE | 4 (best 0.85) |
| 7QSM | Bovine complex I in lipid nanodisc, deactive-ligand (composite) | electron microscopy | h | CDL, 3PE | — |
| 7QSN | Bovine complex I in lipid nanodisc, deactive-apo | electron microscopy | h | CDL, 3PE | — |
| 7QSO | Bovine complex I in lipid nanodisc, State 3 (Slack) | electron microscopy | h | CDL, 3PE | — |
| 7QSO | Bovine complex I in lipid nanodisc, state 3 (slack) | electron microscopy | h | CDL, 3PE | — |
| 7R41 | Bovine complex I in the presence of IM1761092, active class i (Composite map) | electron microscopy | h | CDL, I49 | 4 (best 0.86) |
| 7R43 | Bovine complex I in the presence of IM1761092, active class iii (Composite map) | electron microscopy | h | CDL | — |
| 7R44 | Bovine complex I in the presence of IM1761092, active class iv (Composite map) | electron microscopy | h | CDL, PC1, I49 | 4 (best 0.90) |
| 7R45 | Bovine complex I in the presence of IM1761092, deactive class i (Composite map) | electron microscopy | h | CDL, I49 | 4 (best 0.86) |
| 7R46 | Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) | electron microscopy | h | CDL | 3 (best 0.89) |
| 7R47 | Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) | electron microscopy | h | CDL, I49 | — |
| 7R48 | Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) | electron microscopy | h | CDL, I49 | 4 (best 0.89) |
| 7R4C | Bovine complex I in the presence of IM1761092, deactive class v (Composite map) | electron microscopy | h | CDL, PC1, I49 | 4 (best 0.86) |
| 7R4G | Bovine complex I in the presence of IM1761092, slack class ii (Composite map) | electron microscopy | h | CDL, I49 | 5 (best 0.83) |
| 8Q0A | Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. | electron microscopy | h | CDL, PLC, PC1 | 4 (best 0.84) |
| 8Q0J | Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. | electron microscopy | h | 3PE | 6 (best 0.86) |
| 8Q0M | Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. | electron microscopy | h | CDL, PLC, PC1 | 2 (best 0.84) |
| 8Q1P | Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially… | electron microscopy | h | CDL, PLC, PC1 | 4 (best 0.90) |
| 8Q1U | Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially… | electron microscopy | h | CDL, PLC, PC1 | 2 (best 0.83) |
| 8Q1Y | Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially… | electron microscopy | h | PC1, PLC, 3PE, CDL | 6 (best 0.88) |
| 8Q4A | Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. | electron microscopy | h | CDL, PLC, PC1 | 5 (best 0.87) |
| Q02380 | AlphaFold monomer V2.0 prediction for NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5… | predicted | A | — | — |
Ligands
Experiment against prediction
- 7R4G chain h against the predicted model Q02380: TM-score 0.97, RMSD 0.85 Å
- 7R46 chain h against the predicted model Q02380: TM-score 0.95, RMSD 1.10 Å
- 7R4C chain h against the predicted model Q02380: TM-score 0.95, RMSD 1.10 Å
- 7R47 chain h against the predicted model Q02380: TM-score 0.95, RMSD 1.14 Å
- 7R45 chain h against the predicted model Q02380: TM-score 0.95, RMSD 1.15 Å
- 7R43 chain h against the predicted model Q02380: TM-score 0.95, RMSD 1.15 Å
- 8Q4A chain h against the predicted model Q02380: TM-score 0.95, RMSD 1.13 Å
- 8Q0M chain h against the predicted model Q02380: TM-score 0.94, RMSD 1.14 Å
- 7R48 chain h against the predicted model Q02380: TM-score 0.94, RMSD 1.17 Å
- 7QSD chain h against the predicted model Q02380: TM-score 0.94, RMSD 1.18 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.