UniProt Q01650
Large neutral amino acids transporter small subunit 1 (Q01650)
Large neutral amino acids transporter small subunit 1 (UniProt Q01650): 12 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 25 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q01650
- Protein
- Large neutral amino acids transporter small subunit 1
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 25 · 3 records with a druggable one
Structures
13 records of Q01650 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6IRS | Human LAT1-4F2HC complex incubated with JPH203 | electron microscopy | B | 3PH | — |
| 6IRT | Human LAT1-4F2HC complex bound with bch | electron microscopy | B | 3PH, AUU | — |
| 6JMQ | LAT1-CD98hc complex bound to MEM-108 Fab | electron microscopy | A | CLR | — |
| 6JMQ | LAT1-CD98HC complex bound to mem-108 Fab | electron microscopy | A | CLR | — |
| 7DSK | Overall structure of the LAT1-4F2hc bound with JX-075 | electron microscopy | B | 3PH, HNX, Y01 | — |
| 7DSK | Overall structure of the LAT1-4F2HC bound with jx-075 | electron microscopy | B | 3PH, HNX, Y01 | — |
| 7DSL | Overall structure of the LAT1-4F2hc bound with JX-078 | electron microscopy | B | 3PH, HO0, Y01 | 7 (best 0.83) |
| 7DSL | Overall structure of the LAT1-4F2HC bound with jx-078 | electron microscopy | B | 3PH, HO0, Y01 | — |
| 7DSN | Overall structure of the LAT1-4F2HC bound with jx-119 | electron microscopy | B | 3PH, HO9, Y01 | — |
| 7DSQ | Overall structure of the LAT1-4F2HC bound with 3,5-diiodo-L-tyrosine | electron microscopy | B | Y01, 3PH | — |
| 8J8L | Overall structure of the LAT1-4F2hc bound with L-dopa | electron microscopy | B | DAH | 11 (best 0.82) |
| 8J8M | Overall structure of the LAT1-4F2hc bound with tryptophan | electron microscopy | B | TRP | 7 (best 0.79) |
| Q01650 | AlphaFold monomer V2.0 prediction for large neutral amino acids transporter small subunit 1 (Q01650) | predicted | A | — | — |
Ligands
- 3PH · 1,2-diacyl-glycerol-3-sn-phosphate · in 8 records
- Y01 · Cholesterol hemisuccinate · in 6 records
- CLR · Cholesterol · in 2 records
- HNX · (2~{S})-2-azanyl-7-(naphthalen-1-ylmethoxy)-3,4-dihydro-1~{H}-naphthalene-2-carboxylic acid · in 2 records
- HO0 · (2~{S})-2-azanyl-7-[(2-phenylphenyl)methoxy]-3,4-dihydro-1~{H}-naphthalene-2-carboxylic acid · in 2 records
- AUU · (1S,2S,4R)-2-aminobicyclo[2.2.1]heptane-2-carboxylic acid · in 1 record
- DAH · 3,4-dihydroxyphenylalanine · in 1 record
- HO9 · (2~{S})-2-azanyl-7-[[2-(1,3-benzoxazol-2-yl) phenyl]methoxy]-3,4-dihydro-1~{H}-naphthalene-2-carboxylic acid · in 1 record
- TRP · Tryptophan · in 1 record
Experiment against prediction
- 6IRT chain B against the predicted model Q01650: TM-score 0.96, RMSD 1.64 Å
- 6IRS chain B against the predicted model Q01650: TM-score 0.96, RMSD 1.73 Å
- 6JMQ chain A against the predicted model Q01650: TM-score 0.95, RMSD 1.81 Å
- 6JMQ chain A against the predicted model Q01650: TM-score 0.95, RMSD 1.81 Å
- 7DSL chain B against the predicted model Q01650: TM-score 0.91, RMSD 2.69 Å
- 7DSL chain B against the predicted model Q01650: TM-score 0.91, RMSD 2.69 Å
- 7DSK chain B against the predicted model Q01650: TM-score 0.90, RMSD 2.68 Å
- 7DSK chain B against the predicted model Q01650: TM-score 0.90, RMSD 2.68 Å
- 7DSN chain B against the predicted model Q01650: TM-score 0.90, RMSD 2.78 Å
- 8J8L chain B against the predicted model Q01650: TM-score 0.89, RMSD 2.96 Å
Elsewhere
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