UniProt Q00059
Transcription factor A, mitochondrial (Q00059)
Transcription factor A, mitochondrial (UniProt Q00059): 21 experimental structures and 1 predicted model on GenesisL1, 34 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q00059
- Protein
- Transcription factor A, mitochondrial
- Experimental structures
- 21
- Predicted models
- 1
- Pockets
- 34 · 5 records with a druggable one
Structures
22 records of Q00059 in the MolNFT archive: 21 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3FGH | Human mitochondrial transcription factor A box B | x-ray diffraction | A | — | — |
| 3FGH | Human mitochondrial transcription factor a box B | x-ray diffraction | A | — | — |
| 3TMM | TFAM imposes a U-turn on mitochondrial DNA | x-ray diffraction | A | — | — |
| 3TMM | Tfam imposes a U-turn on mitochondrial DNA | x-ray diffraction | A | — | — |
| 3TQ6 | Crystal structure of human mitochondrial transcription factor A, TFAM or mtTFA, bound to the light… | x-ray diffraction | A, B | — | — |
| 3TQ6 | Crystal structure of human mitochondrial transcription factor a, tfam or mttfa, bound to the light… | x-ray diffraction | A, B | — | — |
| 4NNU | Distinct structural features of TFAM drive mitochondrial DNA packaging versus transcriptional… | x-ray diffraction | A, B | — | — |
| 4NNU | Distinct structural features of tfam drive mitochondrial DNA packaging versus transcriptional… | x-ray diffraction | A, B | — | — |
| 4NOD | Distinct structural features of TFAM drive mitochondrial DNA packaging versus transcriptional… | x-ray diffraction | A, B, G, H | — | — |
| 4NOD | Distinct structural features of tfam drive mitochondrial DNA packaging versus transcriptional… | x-ray diffraction | A, B, G, H | — | — |
| 6ERP | Structure of the human mitochondrial transcription initiation complex at the LSP promoter | x-ray diffraction | C, G | — | 3 (best 0.77) |
| 6ERP | Structure of the human mitochondrial transcription initiation complex at the lsp promoter | x-ray diffraction | C, G | — | — |
| 6ERQ | Structure of the human mitochondrial transcription initiation complex at the HSP promoter | x-ray diffraction | C, G | — | 4 (best 0.71) |
| 6ERQ | Structure of the human mitochondrial transcription initiation complex at the HSP promoter | x-ray diffraction | C, G | — | — |
| 6HB4 | TFAM in Complex with Site-Y | x-ray diffraction | A, D, G, J | — | 13 (best 0.80) |
| 6HB4 | Tfam in complex with site-Y | x-ray diffraction | A, D, G, J | — | — |
| 6HC3 | Tfam bound to site-X | x-ray diffraction | A, D, G, J | — | — |
| 7LBW | Crystal structure of TFAM (mitochondrial transcription factor A) bridging two non-sequence specific… | x-ray diffraction | A, B | — | 6 (best 0.79) |
| 7LBW | Crystal structure of tfam (mitochondrial transcription factor a) bridging two non-sequence specific… | x-ray diffraction | A, B | — | — |
| 7LBX | Crystal structure of TFAM (mitochondrial transcription factor A) in complex with LSP | x-ray diffraction | A, B | — | 7 (best 0.77) |
| 7LBX | Crystal structure of tfam (mitochondrial transcription factor a) in complex with lsp | x-ray diffraction | A, B | — | — |
| Q00059 | AlphaFold monomer V2.0 prediction for transcription factor a, mitochondrial (Q00059) | predicted | A | — | 1 (best 0.28) |
Experiment against prediction
- 3TQ6 chain A against the predicted model Q00059: TM-score 0.99, RMSD 0.40 Å
- 3TQ6 chain A against the predicted model Q00059: TM-score 0.99, RMSD 0.40 Å
- 7LBW chain A against the predicted model Q00059: TM-score 0.97, RMSD 0.99 Å
- 7LBW chain A against the predicted model Q00059: TM-score 0.97, RMSD 0.99 Å
- 3TQ6 chain B against the predicted model Q00059: TM-score 0.96, RMSD 1.03 Å
- 3TQ6 chain B against the predicted model Q00059: TM-score 0.96, RMSD 1.03 Å
- 7LBW chain B against the predicted model Q00059: TM-score 0.96, RMSD 1.06 Å
- 7LBW chain B against the predicted model Q00059: TM-score 0.96, RMSD 1.06 Å
- 7LBX chain A against the predicted model Q00059: TM-score 0.96, RMSD 1.07 Å
- 7LBX chain A against the predicted model Q00059: TM-score 0.96, RMSD 1.07 Å
Elsewhere
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