MolNFT v1 · #147923 · protein + DNA
Structure of the human mitochondrial transcription initiation complex at the HSP promoter
6ERQ · Transcription factor a, mitochondrial: “Structure of the human mitochondrial transcription initiation complex at the HSP promoter”. X-ray diffraction, 20 pockets (best druggability 0.82). MolNFT v1 #147923 on GenesisL1: 3D…
- PDB
- 6ERQ
- Type
- protein + DNA
- Length
- 3,155 residues
- Chains
- 10
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription factor a, mitochondrial; Non-template DNA; Template DNA; DNA-directed RNA…
- EC
- 2.7.7.6, 2.1.1.-
- UniProt
- Q00059, O00411, Q9H5Q4
- Pockets
- 20 · best druggability 0.82
Structure
x-ray diffraction · 6 distinct chains · 58% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C, G | Transcription factor a, mitochondrial | protein | 192 | 73% helix, 0% strand | Q00059 |
| D, H | Non-template DNA | dna | 46 | — | — |
| E, I | Template DNA | dna | 45 | — | — |
| A | DNA-directed RNA polymerase, mitochondrial (EC 2.7.7.6) | protein | 1011 | 59% helix, 8% strand | O00411 |
| B | DNA-directed RNA polymerase, mitochondrial (EC 2.7.7.6) | protein | 1002 | 59% helix, 8% strand | O00411 |
| F, J | Dimethyladenosine transferase 2, mitochondrial (EC 2.1.1.-) | protein | 288 | 43% helix, 15% strand | Q9H5Q4 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 869 | 0.82 | 0.84 | 105 | empty |
| 2 | 1069 | 0.81 | 0.82 | 85 | empty |
| 3 | 576 | 0.76 | 0.83 | 58 | empty |
| 4 | 717 | 0.76 | 0.81 | 106 | empty |
| 5 | 407 | 0.75 | 0.85 | 51 | empty |
Interfaces
20 interfaces between chains.
- D–E · 1975 Ų buried · 145 hydrogen bonds · nucleic-nucleic
- H–I · 1974 Ų buried · 140 hydrogen bonds · nucleic-nucleic
- G–I · 1519 Ų buried · 24 hydrogen bonds · protein-nucleic
- G–H · 1249 Ų buried · 11 hydrogen bonds · protein-nucleic
- C–E · 1229 Ų buried · 16 hydrogen bonds · protein-nucleic
Compared structures
- 6ERQ · Structure of the human mitochondrial transcription initiation complex at the HSP promoter · the same entry in another collection · chain J against J, TM-score 1.00
- Q9H5Q4 · AlphaFold monomer V2.0 prediction for dimethyladenosine transferase 2, mitochondrial… · a predicted model of the same protein · chain F against A, TM-score 0.99
- O00411 · AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase, mitochondrial (O00411) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q00059
- Every structure of UniProt O00411
- Every structure of UniProt Q9H5Q4
- Elsewhere: RCSB PDB 6ERQ · PDBe 6ERQ · UniProt Q00059 · UniProt O00411 · UniProt Q9H5Q4
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