UniProt O00411
DNA-directed RNA polymerase, mitochondrial (O00411)
DNA-directed RNA polymerase, mitochondrial (UniProt O00411), EC 2.7.7.6: 19 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 306 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O00411
- Protein
- DNA-directed RNA polymerase, mitochondrial
- EC
- 2.7.7.6
- Experimental structures
- 19
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 306 · 19 records with a druggable one
Structures
20 records of O00411 in the MolNFT archive: 19 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3SPA | Crystal Structure of Human Mitochondrial RNA Polymerase | x-ray diffraction | A | CL, SO4 | 13 (best 0.78) |
| 3SPA | Crystal structure of human mitochondrial RNA polymerase | x-ray diffraction | A | CL, SO4 | 13 (best 0.78) |
| 4BOC | Structure of mitochondrial RNA polymerase elongation complex | x-ray diffraction | A | — | 17 (best 0.82) |
| 4BOC | Structure of mitochondrial RNA polymerase elongation complex | x-ray diffraction | A | — | 17 (best 0.82) |
| 5OLA | Structure of mitochondrial transcription elongation complex in complex with elongation factor TEFM | x-ray diffraction | E, F | — | 19 (best 0.80) |
| 5OLA | Structure of mitochondrial transcription elongation complex in complex with elongation factor tefm | x-ray diffraction | E, F | — | 19 (best 0.80) |
| 6ERP | Structure of the human mitochondrial transcription initiation complex at the LSP promoter | x-ray diffraction | A, B | — | 19 (best 0.81) |
| 6ERP | Structure of the human mitochondrial transcription initiation complex at the lsp promoter | x-ray diffraction | A, B | — | 19 (best 0.81) |
| 6ERQ | Structure of the human mitochondrial transcription initiation complex at the HSP promoter | x-ray diffraction | A, B | — | 20 (best 0.82) |
| 6ERQ | Structure of the human mitochondrial transcription initiation complex at the HSP promoter | x-ray diffraction | A, B | — | 20 (best 0.82) |
| 7A8P | Structure of human mitochondrial RNA polymerase in complex with IMT inhibitor. | electron microscopy | A | R4Q | 11 (best 0.84) |
| 7A8P | Structure of human mitochondrial RNA polymerase in complex with imt inhibitor. | electron microscopy | A | R4Q | — |
| 7PZP | Mitochondrial DNA dependent RNA polymerase homodimer. | electron microscopy | A, B | — | 20 (best 0.81) |
| 7PZR | Cryo-EM structure of POLRMT in free form. | electron microscopy | A | — | 10 (best 0.80) |
| 7ZC4 | Cryo-EM structure of POLRMT mutant. | electron microscopy | A | — | 9 (best 0.79) |
| 8U8U | Cryo-EM Structure of Cognate Substrate ATP Bound in the Entry Site (ES) of Human Mitochondrial… | electron microscopy | E | APC | 16 (best 0.78) |
| 8U8V | Cryo-EM structure of Substrate ATP Bound in the Insertion Site (IS) of Human Mitochondrial… | electron microscopy | E | APC, MG | 18 (best 0.81) |
| 9BDC | Cryo-EM Structure of TEFM-Bound Human Mitochondrial Transcription Elongation Complex in a Clenched… | electron microscopy | E | — | 14 (best 0.80) |
| 9BDD | Cryo-EM Structure of Non-Cognate Substrate Bound in the Entry Site (ES) of Human Mitochondrial… | electron microscopy | E | APC | 15 (best 0.81) |
| O00411 | AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase, mitochondrial (O00411) | predicted | A | — | 17 (best 0.77) |
Ligands
- APC · Diphosphomethylphosphonic acid adenosyl ester · in 3 records
- CL · Chloride ion · in 2 records
- R4Q · (3~{R})-1-[(2~{R})-2-[4-(2-chloranyl-4-fluoranyl-phenyl)-2-oxidanylidene-chromen-7-yl]oxypropanoyl]piperidine-3-carboxylic acid · in 2 records
- SO4 · Sulfate ion · in 2 records
- MG · Magnesium ion · in 1 record
Experiment against prediction
- 4BOC chain A against the predicted model O00411: TM-score 0.99, RMSD 1.15 Å
- 4BOC chain A against the predicted model O00411: TM-score 0.99, RMSD 1.15 Å
- 7ZC4 chain A against the predicted model O00411: TM-score 0.97, RMSD 1.76 Å
- 7PZR chain A against the predicted model O00411: TM-score 0.97, RMSD 2.08 Å
- 3SPA chain A against the predicted model O00411: TM-score 0.97, RMSD 2.15 Å
- 3SPA chain A against the predicted model O00411: TM-score 0.97, RMSD 2.15 Å
- 7PZP chain A against the predicted model O00411: TM-score 0.96, RMSD 2.23 Å
- 6ERQ chain A against the predicted model O00411: TM-score 0.96, RMSD 2.04 Å
- 6ERQ chain A against the predicted model O00411: TM-score 0.96, RMSD 2.04 Å
- 7PZP chain B against the predicted model O00411: TM-score 0.96, RMSD 2.36 Å
Elsewhere
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