MolNFT v1 · #129466 · protein + DNA + RNA
Structure of mitochondrial transcription elongation complex in complex with elongation factor tefm
5OLA · Transcription elongation factor, mitochondrial: “Structure of mitochondrial transcription elongation complex in complex with elongation factor tefm”. X-ray diffraction, 20 pockets (best druggability 0.80). MolNFT v1 #129466 on…
- PDB
- 5OLA
- Type
- protein + DNA + RNA
- Length
- 2,936 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription elongation factor, mitochondrial; DNA-directed RNA polymerase…
- EC
- 2.7.7.6
- UniProt
- Q96QE5, O00411
- Pockets
- 20 · best druggability 0.80
Structure
x-ray diffraction · 6 distinct chains · 54% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Transcription elongation factor, mitochondrial | protein | 212 | 45% helix, 18% strand | Q96QE5 |
| B, D | Transcription elongation factor, mitochondrial | protein | 207 | 42% helix, 18% strand | Q96QE5 |
| E, F | DNA-directed RNA polymerase, mitochondrial (EC 2.7.7.6) | protein | 989 | 58% helix, 8% strand | O00411 |
| N, G | DNA (5'- D(P*AP*TP*GP*GP*TP*GP*TP*AP*AP*CP*GP*CP*CP*AP*GP*AP*CP*GP*AP*AP*C)- 3') | dna | 21 | — | — |
| R, H | RNA (5'-R(P*GP*CP*GP*GP*CP*GP*CP*GP*C)-3') | rna | 9 | — | — |
| T, I | DNA (30-mer) | dna | 30 | — | — |
Pockets
20 pockets found on a 1 Å grid, 18 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 946 | 0.80 | 0.82 | 63 | empty |
| 2 | 1036 | 0.79 | 0.80 | 93 | empty |
| 3 | 1055 | 0.78 | 0.80 | 86 | empty |
| 4 | 1121 | 0.78 | 0.80 | 84 | empty |
| 5 | 1099 | 0.77 | 0.79 | 81 | empty |
Interfaces
25 interfaces between chains.
- F–I · 1502 Ų buried · 26 hydrogen bonds · protein-nucleic
- E–T · 1489 Ų buried · 20 hydrogen bonds · protein-nucleic
- C–D · 1096 Ų buried · 4 hydrogen bonds · protein-protein
- A–B · 1095 Ų buried · 4 hydrogen bonds · protein-protein
- N–T · 936 Ų buried · 66 hydrogen bonds · nucleic-nucleic
Compared structures
- 5OLA · Structure of mitochondrial transcription elongation complex in complex with elongation… · the same entry in another collection · chain I against I, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96QE5
- Every structure of UniProt O00411
- Elsewhere: RCSB PDB 5OLA · PDBe 5OLA · UniProt Q96QE5 · UniProt O00411
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