UniProt Q96QE5
Transcription elongation factor, mitochondrial (Q96QE5)
Transcription elongation factor, mitochondrial (UniProt Q96QE5): 10 experimental structures and 1 predicted model on GenesisL1, 46 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q96QE5
- Protein
- Transcription elongation factor, mitochondrial
- Experimental structures
- 10
- Predicted models
- 1
- Pockets
- 46 · 5 records with a druggable one
Structures
11 records of Q96QE5 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5OL8 | Structure of human mitochondrial transcription elongation factor (TEFM) C-terminal domain | x-ray diffraction | A, B, C, D | — | 11 (best 0.70) |
| 5OL8 | Structure of human mitochondrial transcription elongation factor (tefm) C-terminal domain | x-ray diffraction | A, B, C, D | — | — |
| 5OL9 | Structure of human mitochondrial transcription elongation factor (TEFM) N-terminal domain | x-ray diffraction | A | — | — |
| 5OL9 | Structure of human mitochondrial transcription elongation factor (tefm) N-terminal domain | x-ray diffraction | A | — | — |
| 5OLA | Structure of mitochondrial transcription elongation complex in complex with elongation factor TEFM | x-ray diffraction | A, B, C, D | — | — |
| 5OLA | Structure of mitochondrial transcription elongation complex in complex with elongation factor tefm | x-ray diffraction | A, B, C, D | — | — |
| 8U8U | Cryo-EM Structure of Cognate Substrate ATP Bound in the Entry Site (ES) of Human Mitochondrial… | electron microscopy | A, B | — | 7 (best 0.78) |
| 8U8V | Cryo-EM structure of Substrate ATP Bound in the Insertion Site (IS) of Human Mitochondrial… | electron microscopy | A, B | — | 8 (best 0.76) |
| 9BDC | Cryo-EM Structure of TEFM-Bound Human Mitochondrial Transcription Elongation Complex in a Clenched… | electron microscopy | A, B | — | 8 (best 0.78) |
| 9BDD | Cryo-EM Structure of Non-Cognate Substrate Bound in the Entry Site (ES) of Human Mitochondrial… | electron microscopy | A, B | — | 9 (best 0.81) |
| Q96QE5 | AlphaFold monomer V2.0 prediction for transcription elongation factor, mitochondrial (Q96QE5) | predicted | A | — | 3 (best 0.43) |
Experiment against prediction
- 5OLA chain A against the predicted model Q96QE5: TM-score 0.99, RMSD 0.63 Å
- 5OLA chain A against the predicted model Q96QE5: TM-score 0.99, RMSD 0.63 Å
- 5OLA chain B against the predicted model Q96QE5: TM-score 0.99, RMSD 0.61 Å
- 5OLA chain B against the predicted model Q96QE5: TM-score 0.99, RMSD 0.61 Å
- 9BDC chain A against the predicted model Q96QE5: TM-score 0.99, RMSD 0.61 Å
- 9BDD chain A against the predicted model Q96QE5: TM-score 0.99, RMSD 0.67 Å
- 5OL8 chain A against the predicted model Q96QE5: TM-score 0.98, RMSD 0.72 Å
- 5OL8 chain A against the predicted model Q96QE5: TM-score 0.98, RMSD 0.72 Å
- 9BDD chain B against the predicted model Q96QE5: TM-score 0.98, RMSD 0.73 Å
- 8U8U chain A against the predicted model Q96QE5: TM-score 0.97, RMSD 0.98 Å
Elsewhere
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