MolNFT v1 · #80096 · protein + DNA
Tfam imposes a U-turn on mitochondrial DNA
3TMM · Transcription factor a, mitochondrial: “Tfam imposes a U-turn on mitochondrial DNA”. X-ray diffraction, 4 pockets (best druggability 0.70). MolNFT v1 #80096 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3TMM
- Type
- protein + DNA
- Length
- 251 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription factor a, mitochondrial; DNA (28-mer)
- UniProt
- Q00059
- Pockets
- 4 · best druggability 0.70
Structure
x-ray diffraction · 3 distinct chains · 73% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcription factor a, mitochondrial | protein | 195 | 73% helix, 0% strand | Q00059 |
| B | DNA (28-mer) | dna | 28 | — | — |
| C | DNA (28-mer) | dna | 28 | — | — |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 717 | 0.70 | 0.77 | 46 | empty |
| 2 | 699 | 0.67 | 0.76 | 42 | empty |
| 3 | 69 | 0.33 | 0.76 | 11 | empty |
| 4 | 95 | 0.30 | 0.72 | 16 | empty |
Interfaces
3 interfaces between chains.
- A–C · 1526 Ų buried · 17 hydrogen bonds · protein-nucleic
- A–B · 1427 Ų buried · 17 hydrogen bonds · protein-nucleic
- B–C · 1211 Ų buried · 104 hydrogen bonds · nucleic-nucleic
Modifications
Observed in the structure: 5 modified (engineered).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q00059
- Elsewhere: RCSB PDB 3TMM · PDBe 3TMM · UniProt Q00059
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