UniProt P81128
Rho GTPase-activating protein 35 (P81128)
Rho GTPase-activating protein 35 (UniProt P81128): 4 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 25 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P81128
- Protein
- Rho GTPase-activating protein 35
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 25 · 3 records with a druggable one
Structures
5 records of P81128 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5IRC | p190A GAP domain complex with RhoA | x-ray diffraction | A, B | CL, GDP, MG, MGF | 6 (best 0.72) |
| 5IRC | P190A gap domain complex with rhoa | x-ray diffraction | A, B | — | — |
| 6D4G | N-GTPase domain of p190RhoGAP-A | x-ray diffraction | A, B | GTP, MG | 5 (best 0.71) |
| 6D4G | N-GTPase domain of P190RHOGAP-a | x-ray diffraction | A, B | GTP, MG | — |
| P81128 | AlphaFold monomer V2.0 prediction for rho GTPase-activating protein 35 (P81128) | predicted | A | — | 14 (best 0.64) |
Ligands
Experiment against prediction
- 6D4G chain B against the predicted model P81128: TM-score 0.99, RMSD 0.66 Å
- 6D4G chain B against the predicted model P81128: TM-score 0.99, RMSD 0.66 Å
- 6D4G chain A against the predicted model P81128: TM-score 0.98, RMSD 1.13 Å
- 6D4G chain A against the predicted model P81128: TM-score 0.98, RMSD 1.13 Å
- 5IRC chain B against the predicted model P81128: TM-score 0.97, RMSD 1.09 Å
- 5IRC chain B against the predicted model P81128: TM-score 0.97, RMSD 1.09 Å
- 5IRC chain A against the predicted model P81128: TM-score 0.96, RMSD 1.50 Å
- 5IRC chain A against the predicted model P81128: TM-score 0.96, RMSD 1.50 Å
Elsewhere
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